Chen Lesnik
Technion – Israel Institute of Technology
6 Papers
34 Citations
Chen Lesnik is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: Mitochondrion & Biology. The author has an hindex of 4, co-authored 5 publications.
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Papers
OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria
TL;DR: This work identifies Saccharomyces cerevisiae outer membrane protein OM14 as the first mitochondrial receptor for ribosome-associated NAC and reveals its importance for import, providing a strong support for an additional, co-translational mode of import into mitochondria.
Uncovering the RNA-binding protein landscape in the pluripotency network of human embryonic stem cells.
Shlomi Dvir,Amir Argoetti,Chen Lesnik,Mark Roytblat,Kohava Shriki,Michal Amit,Tamar Hashimshony,Yael Mandel-Gutfreund +7 more
TL;DR: This article carried out a proteome-wide screen and identified 810 proteins that bind RNA in human embryonic stem cells (hESCs) and revealed that RBPs are preferentially expressed in hESCs and dynamically regulated during early stem cell differentiation.
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The protein chaperone Ssa1 affects mRNA localization to the mitochondria.
TL;DR: A role for Ssa1 is suggested in mediating localization of nascent peptide‐ribosome‐mRNA complexes to the mitochondria, consistent with a co‐translational transport process.
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Isolation of mRNAs associated with yeast mitochondria to study mechanisms of localized translation.
Chen Lesnik,Yoav Arava +1 more
TL;DR: Support for a localized translation process for mitochondrial proteins is derived from recent studies, in which many mRNAs encoding mitochondrial proteins were shown to be localized to the mitochondria vicinity.
Enhanced Branched-Chain Amino Acid Metabolism Improves Age-related Reproductive Function
Chen Lesnik,Salman Sohrabi,Jasmine Ashraf,Rachel Kaletsky,Vanessa Cota,Titas Sengupta,William Keyes,Coleen T. Murphy +7 more
TL;DR: In this paper , the first enzyme of the branched-chain amino acid (BCAA) metabolism pathway, BCAT-1, is more abundant in young and daf-2 mitochondria.