The invention relates to a preparation method of a calcium carbonate/polymer core-shell structure. According to the preparation method, diethylene glycol monovinyl ether is used as a crystal form controlling agent, a shape controlling agent and a polymeric monomer and interface reaction of enabling ultrasonic initiation reactants to collide between organic-phase and water-phase liquid drops is carried out to initiate the monomer to polymerize, so that stable vaterite-phase calcium carbonate/polymer nanoparticles with a (100) face are obtained and the particle size is about 200nm to 300nm.

Preparation method of calcium carbonate/polymer core-shell structure

The invention provides a modified polyethylene glycol and calcium carbonate composite material and a preparation method and application thereof The modified polyethylene glycol and calcium carbonate composite material includes modified polyethylene glycol and nano calcium carbonate growing on the modified polyethylene glycol; the modified polyethylene glycol is obtained by polyethylene glycol grafted with polyamino acid and/or polyacrylic acid Compared with the prior art, the modified polyethylene glycol and calcium carbonate composite material serves as a gene vector masking material, not only can reduce nonspecific adsorption in a blood transportation process, but also can effectively improve the transmission capability of gene carrier on genetic materials and then improves the cell transfection efficiency of gene vectors, and at the same time, the composite material is good in biological compatibility

Modified polyethylene glycol and calcium carbonate composite material and preparation method and application thereof

The invention relates to a gene transmission system and a preparation method thereof, belongs to the technical field of biology and relates to a pH sensitive breakable shielding material, a gene transmission system containing the pH sensitive breakable shielding material and a preparation method thereof. The pH sensitive breakable shielding material provided by the invention is monoacetal polyethylene glycol or dialdehyde polyethylene glycol, which can be connected with cationic polymer genetic vectors through Schiff base reaction in normal tissues; the shielding on the gene transmission system is realized. The gene transmission system provided by the invention comprises the PH sensitive breakable shielding material, a cationic polymer material and a gene substance. In the normal tissues, the gene transmission system contains a shielding layer, so that the uptake of the normal cells on the system is reduced, and the long circulation can be performed in the body; when the material reaches the acidulous tumor tissues, chemical bonds between the shielding material and the cationic polymers fracture; the shielding layer falls off; the tumor cells have high endocytosis efficiency on positive electricity genetic vectors; the efficient transmission of gene substances is realized.

Gene transmission system and preparation method thereof

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Modified polyethylene glycol and calcium carbonate composite material and preparation method and application thereof

Gene transmission system and preparation method thereof