Chen Fan
Chinese Academy of Sciences
7 Papers
Chen Fan is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Colitis & Immune system. The author has an hindex of 6, co-authored 7 publications.
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Papers
Protective role of berberine on ulcerative colitis through modulating enteric glial cells-intestinal epithelial cells-immune cells interactions.
Heng Li,Chen Fan,Huimin Lu,Chunlan Feng,Pei-Lan He,Xiaoqian Yang,Caigui Xiang,Jianping Zuo,Jianping Zuo,Wei Tang +9 more
TL;DR: The study indicated the EGCs–IECs–immune cell interactions might function as a crucial paradigm in mucosal inflammation and provided an infusive mechanism of berberine in regulating enteric neurogenic inflammation.
159
Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity.
Heng Li,Chen Fan,Chunlan Feng,Yanwei Wu,Huimin Lu,Pei-Lan He,Xiaoqian Yang,Fenghua Zhu,Qing Qi,Yuanzhuo Gao,Jianping Zuo,Wei Tang +11 more
TL;DR: This study was designed to explore whether PDE4 inhibition by apremilast exerts protective effects in dextran sulfate sodium‐induced murine UC.
78
Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis
Heng Li,Chunlan Feng,Chen Fan,Yang Yang,Xiaoqian Yang,Huimin Lu,Qiukai Lu,Fenghua Zhu,Caigui Xiang,Zongwang Zhang,Pei-Lan He,Jianping Zuo,Jianping Zuo,Wei Tang +13 more
TL;DR: Berberine significantly attenuated the experimental symptoms and gut inflammation of chronic UC and illustrated that OSM and OSMR intervention might function as the potential target in chronic UC.
RIPK1 inhibitor ameliorates colitis by directly maintaining intestinal barrier homeostasis and regulating following IECs-immuno crosstalk.
Huimin Lu,Heng Li,Chen Fan,Qing Qi,Yu-xi Yan,Yanwei Wu,Chunlan Feng,Bing Wu,Yuanzhuo Gao,Jianping Zuo,Wei Tang +10 more
TL;DR: It is demonstrated that RIPK1 inhibitor could ameliorate the intestinal barrier injury by reducing tight junctions' disruption and accompanying oxidative stress and exerts suppressive function in intestinal inflammatory response.
19
Heme protects intestinal mucosal barrier in DSS-induced colitis through regulating macrophage polarization in both HO-1-dependent and HO-1-independent way
Yanwei Wu,Bing Wu,Zongwang Zhang,Huimin Lu,Chen Fan,Qing Qi,Yuanzhuo Gao,Heng Li,Chunlan Feng,Jianping Zuo,Wei Tang +10 more
TL;DR: Results showed that the modification of colon tissue microenvironment with heme supplementation plays a protective role in DSS‐induced colitis mice through regulating the macrophage polarization in both HO‐1‐dependent and HO‐ 1‐independent way, indicating a new choice to therapeutically modulate the macophage function and prevent IBD.