Chatchawan Singhapol
Newcastle University
4 Papers
17 Citations
Chatchawan Singhapol is an academic researcher from Newcastle University. The author has contributed to research in topics: Induced pluripotent stem cell & Haematopoiesis. The author has an hindex of 4, co-authored 4 publications.
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Papers
Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis.
Chatchawan Singhapol,Deepali Pal,Rafal Czapiewski,Mahendar Porika,Glyn Nelson,Gabriele Saretzki +5 more
TL;DR: It is demonstrated here that mitochondrial localization of telomerase specifically prevents nuclear DNA damage by decreasing levels of mitochondrial ROS, suggesting that this decrease of oxidative stress might be a possible cause for high stress resistance of cancer cells and could be especially important for cancer stem cells.
Brief Report: Human Pluripotent Stem Cell Models of Fanconi Anemia Deficiency Reveal an Important Role for Fanconi Anemia Proteins in Cellular Reprogramming and Survival of Hematopoietic Progenitors
Sun Yung,Katarzyna Tilgner,Maria H. Ledran,Saba Habibollah,Irina Neganova,Chatchawan Singhapol,Gabriele Saretzki,Miodrag Stojkovic,Lyle Armstrong,Stefan Przyborski,Majlinda Lako +10 more
TL;DR: It is reported that FA‐C patient‐specific hiPSC lines can be derived under normoxic conditions, albeit at much reduced efficiency, and these data highlight the critical requirement for FA proteins in survival of hematopoietic progenitors, cellular reprogramming, and maintenance of genomic stability.
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Brief report: a human induced pluripotent stem cell model of cernunnos deficiency reveals an important role for XLF in the survival of the primitive hematopoietic progenitors.
Katarzyna Tilgner,Irina Neganova,Chatchawan Singhapol,Gabriele Saretzki,Jumana Y. Al-Aama,Jerome Evans,Vera Gorbunova,Andrew R. Gennery,Stefan Przyborski,Miodrag Stojkovic,Lyle Armstrong,Penny A. Jeggo,Majlinda Lako +12 more
TL;DR: An induced pluripotent stem cell (iPSC) model of XLF deficiency is generated, which accurately replicates the double‐strand break repair deficiency observed in XLF patients and highlights the importance of NHEJ‐mediated‐DNA repair in the maintenance of a pristine pool of hematopoietic progenitors during human embryonic development.
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A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors.
Katarzyna Tilgner,Katarzyna Tilgner,Irina Neganova,Irina Neganova,Inmaculada Moreno-Gimeno,Jumana Y. Al-Aama,Deborah J. Burks,Sun Yung,Sun Yung,Chatchawan Singhapol,Gabriele Saretzki,Jerry Evans,Vera Gorbunova,Andrew R. Gennery,Stefan Przyborski,Miodrag Stojkovic,Lyle Armstrong,Lyle Armstrong,Penny A. Jeggo,Majlinda Lako,Majlinda Lako +20 more
TL;DR: It is demonstrated that impairment of NHEJ-mediated-DSB repair in human iPSC results in accumulation of DSBs and enhanced apoptosis, thus providing new insights into likely mechanisms used by pluripotent stem cells to maintain their genomic integrity.