Charlie G. Buffie
Memorial Sloan Kettering Cancer Center
8 Papers
11 Citations
Charlie G. Buffie is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Colonisation resistance & Clostridium difficile. The author has an hindex of 8, co-authored 8 publications.
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Papers
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile.
Charlie G. Buffie,Vanni Bucci,Vanni Bucci,Richard R. Stein,Peter T. McKenney,Lilan Ling,Asia Gobourne,Daniel No,Hui Liu,Melissa A. Kinnebrew,Agnes Viale,Eric R. Littmann,Marcel R.M. van den Brink,Marcel R.M. van den Brink,Robert R. Jenq,Ying Taur,Chris Sander,Justin R. Cross,Nora C. Toussaint,Nora C. Toussaint,Joao B. Xavier,Joao B. Xavier,Eric G. Pamer,Eric G. Pamer +23 more
TL;DR: It is determined that Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium, is associated with resistance to C. difficile infection and, upon administration, enhances resistance to infection in a secondary bile Acid dependent fashion.
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Microbiota-mediated colonization resistance against intestinal pathogens.
Charlie G. Buffie,Eric G. Pamer +1 more
TL;DR: How immune- mediated colonization resistance against antibiotic-resistant intestinal pathogens is influenced by the composition of the commensal microbiota is discussed and recent advances characterizing the ability of different Commensal bacterial families, genera and species to restore colonization resistance to intestinal pathogens in antibiotic-treated hosts are reviewed.
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Ecological modeling from time-series inference: insight into dynamics and stability of intestinal microbiota.
Richard R. Stein,Vanni Bucci,Nora C. Toussaint,Charlie G. Buffie,Gunnar Rätsch,Eric G. Pamer,Chris Sander,Joao B. Xavier +7 more
TL;DR: A novel method to infer microbial community ecology directly from time-resolved metagenomics is presented, extending generalized Lotka–Volterra dynamics to account for external perturbations and suggests a subnetwork of bacterial groups implicated in protection against C. difficile.
Profound Alterations of Intestinal Microbiota following a Single Dose of Clindamycin Results in Sustained Susceptibility to Clostridium difficile-Induced Colitis
Charlie G. Buffie,Irene Jarchum,Michele Equinda,Lauren Lipuma,Asia Gobourne,Agnes Viale,Carles Ubeda,Joao B. Xavier,Eric G. Pamer +8 more
TL;DR: It is shown that a single dose of clindamycin markedly reduces the diversity of the intestinal microbiota for at least 28 days, with an enduring loss of ca.
Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense
Melissa A. Kinnebrew,Charlie G. Buffie,Gretchen E. Diehl,Lauren A. Zenewicz,Ingrid Leiner,Tobias M. Hohl,Richard A. Flavell,Richard A. Flavell,Dan R. Littman,Dan R. Littman,Eric G. Pamer +10 more
TL;DR: CD103(+)CD11b(+) LPDCs, in addition to promoting long-term tolerance to ingested antigens, also rapidly produce IL-23 in response to detection of flagellin in the lamina propria.
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