Charles N. Rotimi
National Institutes of Health
285 Papers
1.5K Citations
Charles N. Rotimi is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 69, co-authored 285 publications. Previous affiliations of Charles N. Rotimi include University of Washington & Howard University.
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Papers
The International HapMap Project
John W. Belmont,Paul Hardenbol,Thomas D. Willis,Fuli Yu,Huanming Yang,Lan Yang Ch'Ang,Wei Huang,Bin Liu,Yan Shen,Paul K.H. Tam,Lap-Chee Tsui,Mary M.Y. Waye,Jeffrey Tze Fei Wong,Changqing Zeng,Qingrun Zhang,Mark S. Chee,Luana Galver,Semyon Kruglyak,Sarah S. Murray,Arnold Oliphant,Alexandre Montpetit,Fanny Chagnon,Vincent Ferretti,Martin Leboeuf,Michael S. Phillips,Andrei Verner,Shenghui Duan,Denise L. Lind,Raymond D. Miller,John P. Rice,Nancy L. Saccone,Patricia Taillon-Miller,Ming Xiao,Akihiro Sekine,Koki Sorimachi,Yoichi Tanaka,Tatsuhiko Tsunoda,Eiji Yoshino,David R. Bentley,Sarah E. Hunt,Don Powell,Houcan Zhang,Ichiro Matsuda,Yoshimitsu Fukushima,Darryl Macer,Eiko Suda,Charles N. Rotimi,Clement Adebamowo,Toyin Aniagwu,Patricia A. Marshall,Olayemi Matthew,Chibuzor Nkwodimmah,Charmaine D.M. Royal,Mark Leppert,Missy Dixon,Fiona Cunningham,Ardavan Kanani,Gudmundur A. Thorisson,Peter E. Chen,David J. Cutler,Carl S. Kashuk,Peter Donnelly,Jonathan Marchini,Gilean McVean,Simon Myers,Lon R. Cardon,Andrew P. Morris,Bruce S. Weir,James C. Mullikin,Michael Feolo,Mark J. Daly,Renzong Qiu,Alastair Kent,Georgia M. Dunston,Kazuto Kato,Norio Niikawa,Jessica Watkin,Richard A. Gibbs,Erica Sodergren,George M. Weinstock,Richard K. Wilson,Lucinda Fulton,Jane Rogers,Bruce W. Birren,Hua Han,Hongguang Wang,Martin Godbout,John C. Wallenburg,Paul L'Archevêque,Guy Bellemare,Kazuo Todani,Takashi Fujita,Satoshi Tanaka,Arthur L. Holden,Francis S. Collins,Lisa D. Brooks,Jean E. McEwen,Mark S. Guyer,Elke Jordan,Jane Peterson,Jack Spiegel,Lawrence M. Sung,Lynn F. Zacharia,Karen Kennedy,Michael Dunn,Richard Seabrook,Mark Shillito,Barbara Skene,John Stewart,David Valle,Ellen Wright Clayton,Lynn B. Jorde,Aravinda Chakravarti,Mildred K. Cho,Troy Duster,Troy Duster,Morris W. Foster,Maria Jasperse,Bartha Maria Knoppers,Pui-Yan Kwok,Julio Licinio,Jeffrey C. Long,Pilar N. Ossorio,Vivian Ota Wang,Charles N. Rotimi,Patricia Spallone,Patricia Spallone,Sharon F. Terry,Eric S. Lander,Eric H. Lai,Deborah A. Nickerson,Gonçalo R. Abecasis,David Altshuler,Michael Boehnke,Panos Deloukas,Julie A. Douglas,Stacey Gabriel,Richard R. Hudson,Thomas J. Hudson,Leonid Kruglyak,Yusuke Nakamura,Robert L. Nussbaum,Stephen F. Schaffner,Stephen T. Sherry,Lincoln Stein,Toshihiro Tanaka +145 more
TL;DR: The HapMap will allow the discovery of sequence variants that affect common disease, will facilitate development of diagnostic tools, and will enhance the ability to choose targets for therapeutic intervention.
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Genome-wide detection and characterization of positive selection in human populations
Pardis C. Sabeti,Pardis C. Sabeti,Patrick Varilly,Patrick Varilly,Ben Fry,Jason Lohmueller,Elizabeth Hostetter,Chris Cotsapas,Chris Cotsapas,Xiaohui Xie,Elizabeth H. Byrne,Steven A. McCarroll,Steven A. McCarroll,Rachelle Gaudet,Stephen F. Schaffner,Stephen F. Schaffner,Eric S. Lander,Kelly A. Frazer,Dennis G. Ballinger,David R. Cox,David A. Hinds,Laura L. Stuve,Richard A. Gibbs,John W. Belmont,Andrew Boudreau,Paul Hardenbol,Suzanne M. Leal,Shiran Pasternak,David A. Wheeler,Thomas D. Willis,Fuli Yu,Huanming Yang,Changqing Zeng,Gao Yang,H. B. Hu,Weitao Hu,Chaohua Li,Wei Lin,Siqi Liu,Hao Pan,Xiaoli Tang,Jian Wang,Wei Wang,Jun Yu,Bo Zhang,Qingrun Zhang,Hongbin Zhao,Hui Zhao,Jun Zhou,Stacey Gabriel,Rachel Barry,Brendan Blumenstiel,Amy L. Camargo,Matthew DeFelice,Maura Faggart,Mary Goyette,Supriya Gupta,Jamie Moore,Huy Nguyen,Robert C. Onofrio,Melissa Parkin,Jessica Roy,Erich Stahl,Ellen Winchester,Liuda Ziaugra,David Altshuler,David Altshuler,Yan Shen,Zhijian Yao,Wei Huang,Xun Chu,Yungang He,Li Jin,Yangfan Liu,Yayun Shen,Weiwei Sun,Haifeng Wang,Yi Wang,Ying Wang,Xiaoyan Xiong,Liang Xu,Mary M.Y. Waye,Stephen Kwok-Wing Tsui,Hong Xue,J. Tze Fei Wong,Luana Galver,Jian-Bing Fan,Kevin L. Gunderson,Sarah S. Murray,Arnold Oliphant,Mark S. Chee,Alexandre Montpetit,Fanny Chagnon,Vincent Ferretti,Martin Leboeuf,Jean François Olivier,Michael S. Phillips,Stéphanie Roumy,Clémentine Sallée,Andrei Verner,Thomas J. Hudson,Pui-Yan Kwok,Dongmei Cai,Daniel C. Koboldt,Raymond D. Miller,Ludmila Pawlikowska,Patricia Taillon-Miller,Ming Xiao,Lap-Chee Tsui,William Mak,Qiang Song You,Paul K.H. Tam,Yusuke Nakamura,Takahisa Kawaguchi,Takuya Kitamoto,Takashi Morizono,Atsushi Nagashima,Yozo Ohnishi,Akihiro Sekine,Toshihiro Tanaka,Tatsuhiko Tsunoda,Panos Deloukas,Christine P. Bird,Marcos Delgado,Emmanouil T. Dermitzakis,Rhian Gwilliam,Sarah E. Hunt,Jonathan J. Morrison,Don Powell,Barbara E. Stranger,Pamela Whittaker,David R. Bentley,Mark J. Daly,Mark J. Daly,Paul I.W. de Bakker,Paul I.W. de Bakker,Jeffrey C. Barrett,Jeffrey C. Barrett,Yves Chretien,Julian Maller,Julian Maller,Steve McCarroll,Steve McCarroll,Nick Patterson,Itsik Pe'er,Alkes L. Price,Shaun Purcell,Daniel J. Richter,Richa Saxena,Richa Saxena,Pak C. Sham,Lincoln Stein,Lalitha Krishnan,Albert V. Smith,Marcela K. Tello-Ruiz,Gudmundur A. Thorisson,Aravinda Chakravarti,Peter E. Chen,David J. Cutler,Carl S. Kashuk,Shin Lin,Gonçalo R. Abecasis,Weihua Guan,Yun Li,Heather M. Munro,Zhaohui S. Qin,Daryl J. Thomas,Gilean McVean,Adam Auton,Leonardo Bottolo,Niall Cardin,Susana Eyheramendy,Colin Freeman,Jonathan Marchini,Simon Myers,Chris C. A. Spencer,Matthew Stephens,Peter Donnelly,Lon R. Cardon,Geraldine M. Clarke,David M. Evans,Andrew P. Morris,Bruce S. Weir,Todd A. Johnson,James C. Mullikin,Stephen T. Sherry,Michael Feolo,Andrew D. Skol,Houcan Zhang,Ichiro Matsuda,Yoshimitsu Fukushima,Darryl Macer,Eiko Suda,Charles N. Rotimi,Clement Adebamowo,Ike Ajayi,Toyin Aniagwu,Patricia A. Marshall,Chibuzor Nkwodimmah,Charmaine D.M. Royal,Mark Leppert,Missy Dixon,Andy Peiffer,Renzong Qiu,Alastair Kent,Kazuto Kato,Norio Niikawa,Isaac F. Adewole,Bartha Maria Knoppers,Morris W. Foster,Ellen Wright Clayton,Jessica Watkin,Donna M. Muzny,Lynne V. Nazareth,Erica Sodergren,George M. Weinstock,Imtaz Yakub,Bruce W. Birren,Richard K. Wilson,Lucinda Fulton,Jane Rogers,John Burton,Nigel P. Carter,C M Clee,Mark Griffiths,Matthew C. Jones,Kirsten McLay,Robert W. Plumb,Mark T. Ross,Sarah Sims,David Willey,Zhu Chen,Hua Han,L. Kang,Martin Godbout,John C. Wallenburg,Paul L'Archevêque,Guy Bellemare,Koji Saeki,Hongguang Wang,Daochang An,Hongbo Fu,Qing Li,Zhen Wang,Renwu Wang,Arthur L. Holden,Lisa D. Brooks,Jean E. McEwen,Mark S. Guyer,Vivian Ota Wang,Jane Peterson,Michael Shi,Jack Spiegel,Lawrence M. Sung,Lynn F. Zacharia,Francis S. Collins,Karen Kennedy,Ruth Jamieson,John Stewart +258 more
TL;DR: ‘Long-range haplotype’ methods, which were developed to identify alleles segregating in a population that have undergone recent selection, and new methods that are based on cross-population comparisons to discover alleles that have swept to near-fixation within a population are developed.
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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Georg Ehret,Georg Ehret,Georg Ehret,Patricia B. Munroe,Kenneth Rice,Murielle Bochud,Andrew D. Johnson,Daniel I. Chasman,Albert V. Smith,Martin D. Tobin,Germaine C. Verwoert,Shih-Jen Hwang,Vasyl Pihur,Peter Vollenweider,Paul F. O'Reilly,Najaf Amin,Jennifer L. Bragg-Gresham,Alexander Teumer,Nicole L. Glazer,Lenore J. Launer,Jing Hua Zhao,Yurii S. Aulchenko,Simon Heath,Siim Sõber,Afshin Parsa,Jian'an Luan,Pankaj Arora,Abbas Dehghan,Feng Zhang,Gavin Lucas,Andrew A. Hicks,Anne U. Jackson,John F. Peden,Toshiko Tanaka,Sarah H. Wild,Igor Rudan,Igor Rudan,Wilmar Igl,Yuri Milaneschi,Alex Parker,Cristiano Fava,Cristiano Fava,John C. Chambers,John C. Chambers,Ervin R. Fox,Meena Kumari,Min Jin Go,Pim van der Harst,Wen Hong Linda Kao,Marketa Sjögren,D. G. Vinay,Myriam Alexander,Yasuharu Tabara,Sue Shaw-Hawkins,Peter H. Whincup,Yongmei Liu,Gang Shi,Johanna Kuusisto,Bamidele O. Tayo,Mark Seielstad,Mark Seielstad,Xueling Sim,Khanh-Dung H. Nguyen,Terho Lehtimäki,Giuseppe Matullo,Ying Wu,Tom R. Gaunt,N. Charlotte Onland-Moret,Mark E. Cooper,Carl G. P. Platou,Elin Org,Rebecca Hardy,Santosh Dahgam,Jutta Palmen,Veronique Vitart,Peter S. Braund,Peter S. Braund,Tatiana Kuznetsova,Cuno S.P.M. Uiterwaal,Adebowale Adeyemo,Walter Palmas,Harry Campbell,Barbara Ludwig,Maciej Tomaszewski,Maciej Tomaszewski,Ioanna Tzoulaki,Ioanna Tzoulaki,Nicholette D. Palmer,Thor Aspelund,Melissa Garcia,Yen Pei C. Chang,Jeffrey R. O'Connell,Nanette I. Steinle,Diederick E. Grobbee,Dan E. Arking,Sharon L.R. Kardia,Alanna C. Morrison,Dena G. Hernandez,Samer S. Najjar,Samer S. Najjar,Wendy L. McArdle,David Hadley,David Hadley,Morris J. Brown,John M. C. Connell,Aroon D. Hingorani,Ian N. M. Day,Debbie A Lawlor,John Beilby,Robert W. Lawrence,Robert Clarke,Jemma C. Hopewell,Halit Ongen,Albert W. Dreisbach,Yali Li,J. Hunter Young,Joshua C. Bis,Mika Kähönen,Jorma Viikari,Linda S. Adair,Nanette R. Lee,Ming-Huei Chen,Matthias Olden,Cristian Pattaro,Judith A. Hoffman Bolton,Anna Köttgen,Anna Köttgen,Sven Bergmann,Sven Bergmann,Vincent Mooser,Nish Chaturvedi,Timothy M. Frayling,Muhammad Islam,Tazeen H. Jafar,Jeanette Erdmann,Smita R. Kulkarni,Stefan R. Bornstein,Jürgen Grässler,Leif Groop,Benjamin F. Voight,Johannes Kettunen,Philip Howard,Andrew M. Taylor,Simonetta Guarrera,Fulvio Ricceri,Valur Emilsson,Andrew S. Plump,Inês Barroso,Inês Barroso,Kay-Tee Khaw,Alan B. Weder,Steven C. Hunt,Yan V. Sun,Richard N. Bergman,Francis S. Collins,Lori L. Bonnycastle,Laura J. Scott,Heather M. Stringham,Leena Peltonen,Markus Perola,Erkki Vartiainen,Stefan Martin Brand,Jan A. Staessen,Thomas J. Wang,Thomas J. Wang,Paul Burton,Paul Burton,María Soler Artigas,Yanbin Dong,Harold Snieder,Harold Snieder,Xiaoling Wang,Haidong Zhu,Kurt Lohman,Megan E. Rudock,Susan R. Heckbert,Susan R. Heckbert,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Kerri L. Wiggins,Ayo P. Doumatey,Daniel Shriner,Gudrun Veldre,Margus Viigimaa,Sanjay Kinra,Dorairaj Prabhakaran,Vikal Tripathy,Carl D. Langefeld,Annika Rosengren,Dag S. Thelle,Anna Maria Corsi,Andrew B. Singleton,Terrence Forrester,Gina Hilton,Colin A. McKenzie,Tunde Salako,Naoharu Iwai,Yoshikuni Kita,Toshio Ogihara,Takayoshi Ohkubo,Takayoshi Ohkubo,Tomonori Okamura,Hirotsugu Ueshima,Satoshi Umemura,Susana Eyheramendy,Thomas Meitinger,H.-Erich Wichmann,Yoon Shin Cho,Hyung Lae Kim,Jong-Young Lee,James Scott,Joban Sehmi,Joban Sehmi,Weihua Zhang,Bo Hedblad,Peter M. Nilsson,George Davey Smith,Andrew Wong,Narisu Narisu,Alena Stančáková,Leslie J. Raffel,Jie Yao,Sekar Kathiresan,Sekar Kathiresan,Christopher J. O'Donnell,Christopher J. O'Donnell,Stephen M. Schwartz,M. Arfan Ikram,W. T. Longstreth,Thomas H. Mosley,Sudha Seshadri,Nick Shrine,Louise V. Wain,Mario A. Morken,Amy J. Swift,Jaana Laitinen,Inga Prokopenko,Inga Prokopenko,Paavo Zitting,Jackie A. Cooper,Steve E. Humphries,John Danesh,Asif Rasheed,Anuj Goel,Anders Hamsten,Hugh Watkins,Stephan J. L. Bakker,Wiek H. van Gilst,C. S. Janipalli,K. Radha Mani,Chittaranjan S. Yajnik,Albert Hofman,Francesco U.S. Mattace-Raso,Ben A. Oostra,Ayse Demirkan,Aaron Isaacs,Fernando Rivadeneira,Edward G. Lakatta,Marco Orrù,Angelo Scuteri,Mika Ala-Korpela,Mika Ala-Korpela,Antti J. Kangas,Leo-Pekka Lyytikäinen,Pasi Soininen,Pasi Soininen,Taru Tukiainen,Taru Tukiainen,Taru Tukiainen,Peter Würtz,Peter Würtz,Peter Würtz,Rick Twee-HeeOng,Rick Twee-HeeOng,Marcus Dörr,Heyo K. Kroemer,Uwe Völker,Henry Völzke,Pilar Galan,Serge Hercberg,Mark Lathrop,Diana Zelenika,Panos Deloukas,Massimo Mangino,Tim D. Spector,Guangju Zhai,James F. Meschia,Mike A. Nalls,Pankaj Sharma,Janoš Terzić,M.V. Kranthi Kumar,Matthew Denniff,Ewa Zukowska-Szczechowska,Lynne E. Wagenknecht,F. Gerald R. Fowkes,Fadi J. Charchar,Peter Schwarz,Caroline Hayward,Xiuqing Guo,Charles N. Rotimi,Michiel L. Bots,Eva Brand,Nilesh J. Samani,Nilesh J. Samani,Ozren Polasek,Philippa J. Talmud,Fredrik Nyberg,Fredrik Nyberg,Diana Kuh,Maris Laan,Kristian Hveem,Lyle J. Palmer,Lyle J. Palmer,Yvonne T. van der Schouw,Juan P. Casas,Karen L. Mohlke,Paolo Vineis,Olli T. Raitakari,Santhi K. Ganesh,Tien Yin Wong,Tien Yin Wong,E. Shyong Tai,Richard S. Cooper,Markku Laakso,Dabeeru C. Rao,Tamara B. Harris,Richard W Morris,Anna F. Dominiczak,Mika Kivimäki,Michael Marmot,Tetsuro Miki,Danish Saleheen,Giriraj R. Chandak,Josef Coresh,Gerjan Navis,Veikko Salomaa,Bok Ghee Han,Xiaofeng Zhu,Jaspal S. Kooner,Jaspal S. Kooner,Olle Melander,Paul M. Ridker,Stefania Bandinelli,Ulf Gyllensten,Alan F. Wright,James F. Wilson,Luigi Ferrucci,Martin Farrall,Jaakko Tuomilehto,Peter P. Pramstaller,Roberto Elosua,Nicole Soranzo,Nicole Soranzo,Eric J.G. Sijbrands,David Altshuler,David Altshuler,Ruth J. F. Loos,Alan R. Shuldiner,Alan R. Shuldiner,Christian Gieger,Pierre Meneton,André G. Uitterlinden,Nicholas J. Wareham,Vilmundur Gudnason,Jerome I. Rotter,Rainer Rettig,Manuela Uda,David P. Strachan,Jacqueline C. M. Witteman,Anna-Liisa Hartikainen,Jacques S. Beckmann,Eric Boerwinkle,Ramachandran S. Vasan,Ramachandran S. Vasan,Michael Boehnke,Martin G. Larson,Martin G. Larson,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Bruce M. Psaty,Bruce M. Psaty,Gonçalo R. Abecasis,Aravinda Chakravarti,Paul Elliott,Cornelia M. van Duijn,Christopher Newton-Cheh,Christopher Newton-Cheh,Daniel Levy,Mark J. Caulfield,Toby Johnson +391 more
TL;DR: A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention.
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A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
Valgerdur Steinthorsdottir,Gudmar Thorleifsson,Inga Reynisdottir,Rafn Benediktsson,Thorbjorg Jonsdottir,G. Bragi Walters,Unnur Styrkarsdottir,Solveig Gretarsdottir,Valur Emilsson,Shyamali Ghosh,Adam Baker,Steinunn Snorradottir,Hjordis Bjarnason,Maggie C.Y. Ng,Torben Hansen,Yu Z. Bagger,Robert L. Wilensky,Muredach P. Reilly,Adebowale Adeyemo,Yuanxiu Chen,Jie Zhou,Vilmundur Gudnason,Guanjie Chen,Hanxia Huang,Kerrie Lashley,Ayo Doumatey,Wing-Yee So,Ronald Ching-Wa Ma,Gitte Andersen,Knut Borch-Johnsen,Knut Borch-Johnsen,Knut Borch-Johnsen,Torben Jørgensen,Jana V. van Vliet-Ostaptchouk,Marten H. Hofker,Marten H. Hofker,Cisca Wijmenga,Cisca Wijmenga,Claus Christiansen,Daniel J. Rader,Charles N. Rotimi,Mark E. Gurney,Juliana C.N. Chan,Oluf Pedersen,Oluf Pedersen,Gunnar Sigurdsson,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +49 more
TL;DR: A genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and controls is conducted, and it is found that a previously described variant in the transcription factor 7-like 2 gene (TCF7L2) gene conferred the most significant risk.
A brief history of human disease genetics.
Melina Claussnitzer,Melina Claussnitzer,Melina Claussnitzer,Judy H. Cho,Rory Collins,Nancy J. Cox,Emmanouil T. Dermitzakis,Matthew E. Hurles,Sekar Kathiresan,Sekar Kathiresan,Eimear E. Kenny,Cecilia M. Lindgren,Cecilia M. Lindgren,Daniel G. MacArthur,Daniel G. MacArthur,Kathryn N. North,Sharon E. Plon,Sharon E. Plon,Heidi L. Rehm,Neil Risch,Charles N. Rotimi,Jay Shendure,Jay Shendure,Nicole Soranzo,Nicole Soranzo,Mark I. McCarthy +25 more
TL;DR: Progress is described in the study of human genetics, in which rapid advances in technology, foundational genomic resources and analytical tools have contributed to the understanding of the mechanisms responsible for many rare and common diseases and to preventative and therapeutic strategies for many of these conditions.