Charles Joyce
National Institutes of Health
8 Papers
79 Citations
Charles Joyce is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cholesterol & Reverse cholesterol transport. The author has an hindex of 8, co-authored 8 publications.
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Papers
The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice.
Charles Joyce,Marcelo Amar,Gilles Lambert,Boris L. Vaisman,Beverly Paigen,Jamila Najib-Fruchart,Robert F. Hoyt,Edward D. Neufeld,Alan T. Remaley,Donald S. Fredrickson,H. Bryan Brewer,Silvia Santamarina-Fojo +11 more
TL;DR: It is established that, in the presence of apoE, overexpression of ABCA1 modulates HDL as well as apoB-containing lipoprotein metabolism and reduces atherosclerosis in vivo, and indicate that pharmacological agents that will increaseABCA1 expression may reduce atherogenic risk in humans.
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ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice.
Boris L. Vaisman,Gilles Lambert,Marcelo Amar,Charles Joyce,Toshimitsu Ito,Robert D. Shamburek,William Cain,Jamila Fruchart-Najib,Edward D. Neufeld,Alan T. Remaley,H. Bryan Brewer,Silvia Santamarina-Fojo +11 more
TL;DR: St steady-state overexpression of ABCA1 in vivo raises plasma apoB levels without altering apo B secretion and raises plasma HDL-C and apoA-I levels, facilitating hepatic reverse cholesterol transport and biliary cholesterol excretion.
Study of ABCA1 Function in Transgenic Mice
TL;DR: A review of the most recent studies of ABCA1-Tg mice discusses insights provided by these transgenic mouse models and suggests promising areas of investigation for future investigation.
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ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of Pro-atherogenic lipoproteins and enhanced atherosclerosis
Charles Joyce,Elke M. Wagner,Federica Basso,Marcelo Amar,Lita A. Freeman,Robert D. Shamburek,Catherine L. Knapper,Jafri Syed,Justina C. Wu,Boris L. Vaisman,Jamila Fruchart-Najib,Eric M. Billings,Beverly Paigen,Alan T. Remaley,Silvia Santamarina-Fojo,H. Bryan Brewer +15 more
TL;DR: Hematic overexpressing ABCA1 in the liver of LDLr-KO mice leads to an expansion of the pro-atherogenic apoB-lipoprotein cholesterol pool size via enhanced transfer of HDL-cholesterol to apoF- Lipoproteins and delayed catabolism of cholesterol-enriched apoBs, resulting in up-regulated hepatobiliary sterol secretion.
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Hepatic ABCG5 and ABCG8 Overexpression Increases Hepatobiliary Sterol Transport but Does Not Alter Aortic Atherosclerosis in Transgenic Mice
Justina E Wu,Federica Basso,Robert D. Shamburek,Marcelo Amar,Boris L. Vaisman,Gergeley Szakacs,Charles Joyce,Terese Tansey,Lita A. Freeman,Beverly Paigen,Fairwell Thomas,H. Bryan Brewer,Silvia Santamarina-Fojo +12 more
TL;DR: It is demonstrated that overexpression of ABCG5/G8 in the liver profoundly alters hepatic but not intestinal sterol transport, identifying distinct roles for liver and intestinal ABCG4/G7 in modulating sterol metabolism.
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