Charles Jester
University of Pennsylvania
7 Papers
5 Citations
Charles Jester is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Frontotemporal lobar degeneration & Frontotemporal dementia. The author has an hindex of 5, co-authored 7 publications.
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Papers
Longitudinal decline in speech production in Parkinson's disease spectrum disorders
Sharon Ash,Charles Jester,Collin York,Olga L. Kofman,Rachel Langey,Amy Halpin,Kim Firn,Sophia Dominguez Perez,Lama M. Chahine,Meredith Spindler,Nabila Dahodwala,David J. Irwin,Corey T. McMillan,Daniel Weintraub,Murray Grossman +14 more
TL;DR: Regression analysis in a subset of patients with MRI scans revealed that impaired language performance at Time 2 was associated with reduced gray matter (GM) volume at Time 1 in regions of interest important for language functioning but not with reduced GM volume in motor brain areas.
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Perfusion alterations converge with patterns of pathological spread in transactive response DNA-binding protein 43 proteinopathies
Pilar M. Ferraro,Charles Jester,Christopher Olm,Katerina Placek,Federica Agosta,Lauren Elman,Leo McCluskey,David J. Irwin,John A. Detre,Massimo Filippi,Murray Grossman,Corey T. McMillan +11 more
TL;DR: Perfusion is evaluated as an early marker for incipient pathology-associated brain alterations in TDP-43 proteinopathies and correlated with cognitive and behavioral impairments as investigated and Philadelphia Brief Assessment of Cognition in bvFTD.
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Narrative Organization Deficit in Lewy Body Disorders Is Related to Alzheimer Pathology.
Murray Grossman,David J. Irwin,Charles Jester,Amy Halpin,Sharon Ash,Katya Rascovsky,Daniel Weintraub,Corey T. McMillan +7 more
TL;DR: Findings are consistent with the hypothesis that CSF markers of AD pathology associated with frontal regions play a role in difficulty organizing narratives in LBD.
Clinical Correlates of Alzheimer's Disease Cerebrospinal Fluid Analytes in Primary Progressive Aphasia.
Catherine Norise,Molly Ungrady,Amy Halpin,Charles Jester,Corey T. McMillan,David J. Irwin,Katheryn A.Q. Cousins,Murray Grossman +7 more
TL;DR: The lvPPA clinical phenotype may be a useful screen for CSF analytes that are a surrogate for likely AD pathology, and may help establish eligibility of these patients for disease-modifying treatment trials.
Divergent patterns of TDP-43 and tau pathologies in primary progressive aphasia.
Lucia A. A. Giannini,Lucia A. A. Giannini,Sharon X. Xie,Corey T. McMillan,Mendy Liang,Andrew Williams,Charles Jester,Katya Rascovsky,David A. Wolk,Sharon Ash,Edward B. Lee,John Q. Trojanowski,Murray Grossman,David J. Irwin +13 more
TL;DR: To measure postmortem burden of frontotemporal lobar degeneration with TDP‐43 (FTLD‐TDP) or tau (FT LD‐Tau) proteinopathy across hemispheres in primary progressive aphasia (PPA) using digital histopathology and to identify clinicopathological correlates of these distinct proteinopathies.