Charles B. Nemeroff
University of Texas at Austin
1011 Papers
10.8K Citations
Charles B. Nemeroff is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Medicine & Depression (differential diagnoses). The author has an hindex of 149, co-authored 979 publications. Previous affiliations of Charles B. Nemeroff include Utrecht University & University of Washington.
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Papers
Efficacy and safety of TS-121, a novel vasopressin V1B receptor antagonist, as adjunctive treatment for patients with major depressive disorder: A randomized, double-blind, placebo-controlled study.
Makoto Kamiya,Helene D. Sabia,Julie Marella,Maurizio Fava,Charles B. Nemeroff,Hideo Umeuchi,Michihiko Iijima,Shigeyuki Chaki,Izumi Nishino +8 more
TL;DR: Higher baseline urinary and hair cortisol levels were associated with a greater separation between TS-121 groups and the placebo group in the primary endpoint, and these findings, combined with favorable safety and tolerability, warrant further investigation ofTS-121 in an adequately powered study in patients with MDD.
Failure to Recover from Proactive Semantic Interference Differentiates Amnestic Mild Cognitive Impairment and PreMCI from Normal Aging after Adjusting for Initial Learning Ability
Rosie E. Curiel,Elizabeth Crocco,Arlene Raffo,Salvador M. Guinjoan,Charles B. Nemeroff,Ailyn Penate,Daema Piña,David A. Loewenstein +7 more
- 14 Jun 2018
TL;DR: It is clear that frPSI deficits occur with much greater frequency in individuals at higher risk for Alzheimer’s disease (AD), and likely reflect a failure of brain compensatory mechanisms.
Differential functional connectivity within an emotion regulation neural network among individuals resilient and susceptible to the depressogenic effects of early life stress.
Josh M. Cisler,George Andrew James,Shanti P. Tripathi,Tanja M. Mletzko,Christine Heim,Xiaoping Hu,Helen S. Mayberg,Charles B. Nemeroff,Clinton D. Kilts +8 more
TL;DR: Functional neural connectivity patterns specific to ELS exposure and resiliency versus susceptibility to the depressogenic effects of ELS exposed individuals are suggested.
•Journal Article
The effects of alprazolam on corticotropin-releasing factor neurons in the rat brain: acute time course, chronic treatment and abrupt withdrawal.
TL;DR: The hypothesis that both acute and chronic alprazolam administration alters CRF-containing neurons innervating the locus coeruleus is supported, because many of the signs and symptoms observed in animals and humans after abrupt discontinuation of benzodiazepines resemble the stress response.
5a-Pregnane-3a,21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam
TL;DR: The preliminary findings suggest that, at the dose and time point studied, THDOC does not identically mimic the actions of alprazolam, another drug which potentiates GABAergic activity.