A new luminescent metal-organic framework nanoflower material CJLU-1 (Zr6(3-O)4(3-OH)4(OH)6(TCA)2(H2O)6) (H3TCA= tri-carboxylic acids 4,4′,4″-nitrilotribenzoic acid) have been realized for the highly sensitive sensing of nitroaromatic molecules with fast response. CJLU-1 consists...

Zr-MOF Nanoflower Sensor and Its Mixed-Matrix Membrane for Highly Sensitive Nitroaromatics Detection

DNA-Encoded MXene-Pt Nanozyme for Enhanced Colorimetric Sensing of Mercury Ions

A novel electrochemiluminescence (ECL) Janus emitter realizes dual‐mode biosensing for multiple disease‐related biomarkers from cells. Each Janus emitter consists of ruthenium (II) complex and luminol polymer doped hemispheres that are spatially separated but function simultaneously, generating intense dual‐ECL emissions. This design effectively eliminates optical and electrochemical interferences between different ECL mono‐luminophores in comparison with the homogenous nanostructures, thereby improving ECL efficiency and detection sensitivity. Accordingly, the ECL Janus emitters provide a proof of concept for the construction of the ratiometric ECL sensing of H2O2. Furthermore, this Janus emitter enables simultaneous identification and quantification of the intracellular cancer‐related dual microRNAs. This work not only inspires the development of ECL Janus emitters, but also highlights their potential in bioanalysis and clinical diagnosis in the future.

A Novel Electrochemiluminescence Janus Emitter for Dual‐Mode Biosensing

In this work, a new MOF Eu-BTC-BDC-NH2 (BTC = benzene-1,3,5-tricarboxylate, BDC-NH2 = 2-aminoterephthalic acid) was synthesized by a facile and energy-efficient process, and can be utilized as a highly sensitive and selective ratiometric fluorescence probe for phosphate (Pi). The produced Eu-MOF had two emission peaks at 425 nm and 617 nm, which came from the BDC-NH2 ligand and energy transfer effect between the two ligands and Eu3+, respectively. When contact with Pi, due to the ultra-high affinity between Eu3+ and the oxygen atoms in Pi, part of the ligands were replaced and P-O-Eu bonds formed. Accordingly, the energy transfer effect was weakened, and the fluorescence intensity at 617 nm reduced, however, the peak at 425 nm increased. Based on this, a Pi ratiometric fluorescence platform with excellent performance was established with a low detection limit (LOD) of 0.07 μM and superior selectivity for 19 common ions and 6 phosphate-containing molecules. In addition, the sensor achieved satisfactory results in the detection of environmental water samples. Finally, a portable detection kit based on hydrogel-MOFs was successfully constructed by combining with a smartphone, which can realize on-site monitoring of Pi. 

Preparation of dual-ligands Eu-MOF nanorods with dual fluorescence emissions for highly sensitive and selective ratiometric/visual fluorescence sensing phosphate

Population growth and industrial development have exacerbated environmental pollution of both land and aquatic environments with toxic and harmful materials. Luminescence-based chemical sensors crafted for specific hazardous substances operate on host-guest interactions, leading to the detection of target molecules down to the nanomolar range. Particularly, the luminescence-based sensors constructed on the basis of metal-organic frameworks (MOFs) are of increasing interest, as they can not only compensate for the shortcomings of traditional detection techniques, but also can provide more sensitive detection for analytes. Recent years have seen MOFs-based fluorescent sensors show outstanding advantages in the field of hazardous substance identification and detection. Here, we critically discuss the application of MOFs for the detection of a broad scope of hazardous substances, including hazardous gases, heavy metal ions, radioactive ions, antibiotics, pesticides, nitro-explosives, and some harmful solvents as well as luminous and sensing mechanisms of MOF-based fluorescent sensors. The outlook and several crucial issues of this area are also discussed, with the expectation that it may help arouse widespread attention on exploring fluorescent MOFs (LMOFs) in potential sensing applications.

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Recent Progress in Metal-Organic Framework Based Fluorescent Sensors for Hazardous Materials Detection

Facile synthesis of binary two-dimensional lanthanide metal-organic framework nanosheets for ratiometric fluorescence detection of mercury ions.

Developing a coreactant-free ratiometric electrochemiluminescence (ECL) strategy based on a single luminophore to achieve more accurate and sensitive microRNA (miRNA) detection is highly desired. Herein, utilizing zinc-metal organic frameworks (Zn-MOFs) as the single luminophore, a novel dual-potential ratiometric ECL biosensor was constructed for ultrasensitive detection of miRNA-133a. The as-prepared Zn-MOFs exhibited simultaneous cathode and anode ECL emission. Furthermore, the Zn-MOFs were confirmed to be a multichannel ECL sensing platform with excellent annihilation and coreactant ECL emission. The corresponding ECL behaviors were investigated in detail. Benefiting from the hybridization chain reaction (HCR) amplification technology, N,N-diethylethylenediamine (DEAEA) was modified on hairpin DNA, and the gained products loaded with quantities of DEAEA enhanced the anodic ECL intensity of Zn-MOFs. In the presence of miRNA-133a, the ECL intensity ratio of anode to cathode (Ia/Ic) was significantly increased, which realized the ultrasensitive ratiometric detection of miRNA-133a. In addition, without an exogenous coreactant, the biosensor revealed superb accuracy and stability. Under optimal conditions, the detection linearity of miRNA-133a was from 50 aM to 50 fM with a low detection limit of 35.8 aM (S/N = 3). This is the first work to use Zn-MOFs as a single emitter for reliable ratiometric ECL bioanalysis, which provides a new perspective for fabricating a ratiometric ECL biosensor platform.

Zinc-Metal Organic Frameworks: A Coreactant-free Electrochemiluminescence Luminophore for Ratiometric Detection of miRNA-133a.

One-component nano-metal-organic frameworks with superior multienzyme-mimic activities for 1,4-dihydropyridine metabolism.

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Papers

Facile synthesis of binary two-dimensional lanthanide metal-organic framework nanosheets for ratiometric fluorescence detection of mercury ions.

Zinc-Metal Organic Frameworks: A Coreactant-free Electrochemiluminescence Luminophore for Ratiometric Detection of miRNA-133a.

One-component nano-metal-organic frameworks with superior multienzyme-mimic activities for 1,4-dihydropyridine metabolism.