Changlei Bao

TL;DR: This study demonstrates that T MAO is increased in severe PH, and the reduction of TMAO decreases pulmonary vascular muscularization and alleviates PH via suppressing the macrophage production of chemokines and cytokines.

TL;DR: Findings provide compelling evidence that S-RBD could induce persistent pulmonary vascular endothelial damage by binding to ACE2 and triggering [Ca^2+]_i through upregulation of Piezo1 and Orai1 and Targeted inhibition of ACE2-Piezo1/SOCC-[Ca^1+]-i axis proves a powerful strategy to treat S- RBD-induced pulmonary vascular diseases.

TL;DR: In this paper , the authors established a left pulmonary artery ligation (LPAL)-induced pulmonary hypertension (PH) rat model and investigated the association between gut microbiota composition and host metabolome signatures (in both gut and lung tissues) by using multiomics and correlation analysis.

TL;DR: Results indicate that treatment with ARS or DHA can inhibit PA vasoconstriction, PASMC proliferation and migration, and vascular remodeling, as well as improve PA endothelium-dependent relaxation, and eventually attenuate the development and progression of PH.