Changjiang Sun
Jilin University
88 Papers
259 Citations
Changjiang Sun is an academic researcher from Jilin University. The author has contributed to research in topics: Biology & Bacteriophage. The author has an hindex of 20, co-authored 78 publications.
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Papers
A method for generation phage cocktail with great therapeutic potential.
Jingmin Gu,Xiaohe Liu,Yue Li,Wenyu Han,Liancheng Lei,Yongjun Yang,Honglei Zhao,Yu Gao,Jun Song,Rong Lu,Changjiang Sun,Xin Feng +11 more
TL;DR: The data showed that the phage cocktail established by the SBS method has great therapeutic potential for multidrug-resistant bacteria infection, and was more effective in reducing bacterial mutation frequency and in the rescue of murine bacteremia than monophage.
LysGH15, a Novel Bacteriophage Lysin, Protects a Murine Bacteremia Model Efficiently against Lethal Methicillin-Resistant Staphylococcus aureus Infection
Jingmin Gu,Wei Xu,Liancheng Lei,Jing Huang,Xin Feng,Changjiang Sun,Chongtao Du,Jing Zuo,Yang Li,Taofeng Du,Linxi Li,Wenyu Han +11 more
TL;DR: Results indicate that LysGH15 can kill S. aureus in vitro and can protect mice efficiently from bacteremia in vivo, suggesting it might be an alternative treatment strategy for infections caused by MRSA.
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The Bacteriophage EF-P29 Efficiently Protects against Lethal Vancomycin-Resistant Enterococcus faecalis and Alleviates Gut Microbiota Imbalance in a Murine Bacteremia Model.
Mengjun Cheng,Jiaming Liang,Yufeng Zhang,Liyuan Hu,Pengjuan Gong,Ruopeng Cai,Lei Zhang,Hao Zhang,Jinli Ge,Yalu Ji,Zhimin Guo,Xin Feng,Changjiang Sun,Yongjun Yang,Liancheng Lei,Wenyu Han,Wenyu Han,Jingmin Gu +17 more
TL;DR: The isolated phage EF-P29 showed high efficiency and a broad host range against E. faecalis strains, and showed great potential as a therapeutic treatment for systemic VREF infection, indicating that phage therapies that are aimed at treating opportunistic pathogens are also feasible.
Three Capsular Polysaccharide Synthesis-Related Glucosyltransferases, GT-1, GT-2 and WcaJ, Are Associated With Virulence and Phage Sensitivity of Klebsiella pneumoniae
Ruopeng Cai,Gang Wang,Shuai Le,Mei Wu,Mengjun Cheng,Zhimin Guo,Yalu Ji,Hengyu Xi,Caijun Zhao,Xinwu Wang,Yibing Xue,Zijing Wang,Hao Zhang,Yunhe Fu,Changjiang Sun,Xin Feng,Liancheng Lei,Yongjun Yang,Sadeeq ur Rahman,Xiaoyun Liu,Wenyu Han,Wenyu Han,Jingmin Gu +22 more
TL;DR: This study defines, for the first time, the potential roles of GT-1, GT-2, and WcaJ in K. pneumoniae in bacterial virulence and generation of rough-type mutation under the pressure of bacteriophage.
Characterization of Enterococcus faecium bacteriophage IME-EFm5 and its endolysin LysEFm5
Pengjuan Gong,Mengjun Cheng,Xinwei Li,Haiyan Jiang,Chuang Yu,Nadire Kahaer,Juecheng Li,Lei Zhang,Feifei Xia,Liyuan Hu,Changjiang Sun,Xin Feng,Liancheng Lei,Wenyu Han,Jingmin Gu +14 more
TL;DR: The mutagenesis analysis revealed that the zinc ion binding residues (H27, H132, and C140), E90, and T138 are required for the catalysis of LysEFm5, and the antibacterial activity of Lys EFm5 is zinc ion independent, which is inconsistent with most of other amidase members.
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