Chang He
4 Papers
Chang He is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has co-authored 3 publications.
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Papers
Two major genes associated with autoimmune arthritis, Ncf1 and Fcgr2b, additively protect mice by strengthening T cell tolerance
Qijing Li,Jianghong Zhong,Huqiao Luo,Vilma Urbonaviciute,Zhongwei Xu,Chang He,Rikard Holmdahl +6 more
TL;DR: Zhang et al. as discussed by the authors used a new mouse strain BQ .Col2 266E with homozygous D266E mutations in the Col2 gene leading to a replacement of the endogenous aspartic acid (D) to glutamic acid (E) at position 266 of the COL2 259-273 peptide, resulting in stronger binding to A q .
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NCF4 dependent intracellular reactive oxygen species regulate plasma cell formation
Chang He,Huqiao Luo,Ana Coelho,Meng Liu,Qijing Li,Jing Xu,Alexander Krämer,Stephen Malin,Zuyi Yuan,Rikard Holmdahl +9 more
TL;DR: In this article , the authors used mice harboring a mutation in the lipid endosomal membrane binding site (R58A) of NCF4 subunit to enhance the production of autoantibodies to collagen type II (COL2) and severe collagen-induced arthritis in mice.
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NCF4 regulates antigen presentation of cysteine peptides by intracellular oxidative response and restricts activation of autoreactive and arthritogenic T cells
Jing Xu,Chang He,Yongsong Cai,Xipeng Wang,Jidong Yan,Jing Zhang,Fujun Zhang,Vilma Urbonaviciute,Yuanyuan Cheng,Shemin Lu,Rikard Holmdahl +10 more
TL;DR: NCF4 regulates antigen presentation by controlling intracellular oxidative response, maintaining cysteine peptides in an oxidized state, and restricting activation of autoreactive and arthritogenic T cells, thereby protecting against autoimmune arthritis.
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