Chandrakant Waghmare
Defence Research and Development Establishment
12 Papers
65 Citations
Chandrakant Waghmare is an academic researcher from Defence Research and Development Establishment. The author has contributed to research in topics: Chemistry & Acetylcholinesterase. The author has an hindex of 6, co-authored 10 publications.
Chat about Author
Papers
Differential mRNA expression of acetylcholinesterase in the central nervous system of rats with acute and chronic exposure of sarin & physostigmine
TL;DR: The acute single subcutaneous administration of sarin for short‐term as well as chronic long‐term studies showed that AChE inhibition alone does not lead to observed changes in mRNA expression of A cholinesterase gene, suggesting that route of administration aswell as dose exposure regimen also contributes to the regulation of A ChE mRNA expression.
25
Mass spectral studies of silyl derivatives of partially hydrolyzed products of nitrogen mustards: Important markers of nitrogen mustard exposure.
TL;DR: The study of the two different derivatives of pH pNMs using both EI and CI mass spectrometry provides a reliable, unambiguous identification of pHpNMs in complex environmental and biomedical matrices during any verification activities.
18
Gene expression and phosphoprotein profile of certain key neuronal signaling proteins following soman intoxication.
TL;DR: Exposure to soman caused persistent changes in these key brain proteins, which could lead to the development of complex neurotoxic effects and there is an urgent need for development of better drugs to stop multiple effects of nerve agents poisoning.
17
Mass spectral fragmentation of perfluoroacyl derivatives of half nitrogen mustards for their detection by gas chromatography/mass spectrometry.
TL;DR: This is the first report of the elucidation of the fragmentation pathways of perfluroacyl derivatives of halfNMs and the background-free chromatogram obtained using these derivatives provides unambiguous identification of these compounds in blind samples.
12
Soman-induced alterations of protein kinase C isozymes expression in five discrete areas of the rat brain.
TL;DR: A possible role of PKC isozymes in nerve-agent–induced neurotoxicity is suggested in different rat-brain areas as well as in plasma and brain up to 3 days post exposure and thereafter recovered to control levels.
12