Chanchal Gupta
8 Papers
98 Citations
Chanchal Gupta is an academic researcher. The author has contributed to research in topics: Histone H3 & Apoptosis. The author has an hindex of 7, co-authored 8 publications.
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Papers
Tannic acid ameliorates doxorubicin-induced cardiotoxicity and potentiates its anti-cancer activity: Potential role of tannins in cancer chemotherapy
TL;DR: This is the first report which shows that tannic acid ameliorates doxorubicin-induced cardiotoxicity and potentiates its anti-cancer activity both in vitro (H9c2 and MDA-MB-231 cells) as well as in in vivo model of DMBA-induced mammary tumor animals.
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5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats.
TL;DR: Combination of 5-azacytidine with cisplatin attenuates the cisPlatin induced nephrotoxicity and potentiates the anti-cancer activity which can have profound clinical implications.
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Regulation of MDA-MB-231 cell proliferation by GSK-3β involves epigenetic modifications under high glucose conditions.
TL;DR: To the best of the knowledge, this is the first report which shows that interplay between GSK-3β activation, histone H3 phosphorylation and DNA methylation directs proliferation of breast cancer cells.
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Quercetin inhibits diethylnitrosamine-induced hepatic preneoplastic lesions in rats.
TL;DR: Results clearly indicate that quercetin inhibits diethylnitrosamine-induced hepatic preneoplastic lesions in medium-term rat liver bioassay.
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Alteration in inflammatory/apoptotic pathway and histone modifications by nordihydroguaiaretic acid prevents acute pancreatitis in swiss albino mice
TL;DR: This is the first report which suggests that NDGA prevents the progression of acute pancreatitis by involving alteration of histone H3 modifications and modulating the expression of genes involved in inflammatory/apoptotic cascade, which may be responsible for decreased necrosis and increased apoptosis in this model of acute pancitis.
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