A new liquid chromatographic method with increased sensitivity has been developed for the determination of isocyanates common in industrial environments The isocyanates are converted to stable urea derivatives by reaction with 9-(N-methylaminomethyl)-anthracene These derivatives were analyzed using high performance liquid chromatography on a bonded octadecylsilyl phase using isocratic elution with acetonitrile/water and detected either by a UV or a fluorescence detector The method was applied to toluene 2, 4- and 2, 6-diisocyanate (2, 4- and 2, 6-TDI), hexamethylene diisocyanate (HDI) and 4, 4-diphenylmethane diisocyanate (MDI) The influence of various salts on the retention of the reagent amine was studied, as well as the separation of the urea derivatives on different C18-phases The detection limit is about 1 · 10−4 mg/m3 for the isocyanates investigated, using either UV or fluorescence detection This means that the new method is ten to twenty times more sensitive than the previously desc

A New Reagent for Determination of Isocyanates in Working Atmospheres by HPLC Using UV or Fluorescence Detection

Refractive index gradients in stopped-flow and temperature-jump kinetics and liquid chromatography

Isocyanates common in industrial environments were converted to urea derivatives by reaction with N-4-nitrobenzyl-N-n-propylamine. The urea derivatives were analyzed by high performance liquid chromatography on a bonded octadecylsilyl phase using isocratic elution with acetonitrile-water 75:25 v/v. The water phase contained 1% triethylamine and was adjusted to pH 3.0 with phosphoric acid. The method was applied to toluene 2,4- and 2,6-diisocyanate (2,4- and 2,6-TDI), hexamethylene diisocyanate (HDI), 4,4′-diphenylmethane diisocyanate (MDI) and Desmodur N 75 (DN 75). Comparison with previous liquid chromatographic methods shows that the elution time is about halved and the detection limits about five times lower in our case.

Improved Method for Determination of Traces of Isocyanates in Working Atmospheres by High Performance Liquid Chromatography

Organic analysis by ion chromatography. 1. Determination of aromatic amines and aromatic diisocyanates by cation-exchange chromatography with amperometric detection.

Determination of isocyanates in air by liquid chromatography with fluorescence detection

Simple ureas derived from diisocyanates and their liquid chromatography on a 5-cm column

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Simple ureas derived from diisocyanates and their liquid chromatography on a 5-cm column