Chan Chen
8 Papers
Chan Chen is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 6 publications.
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Papers
Lactate-induced mtDNA Accumulation Activates cGAS-STING Signaling and the Inflammatory Response in Sjögren's Syndrome
Jiabao Xu,Chan Chen,Junhao Yin,Jiayao Fu,X. Yang,Baoli Wang,Chuangqi Yu,Lingyan Zheng,Zhiyuan Zhang +8 more
TL;DR: Inflammatory cytokine production and pathway activation were inhibited in vivo and in vitro by the lactate scavenger sodium dichloroacetate (DCA), which provides new insights into the etiology and treatment of pSS from the perspective of cell metabolism.
12
HECT, UBA and WWE domain containing 1 represses cholesterol efflux during CD4+ T cell activation in Sjögren’s syndrome
Junhao Yin,Jiabao Xu,Chan Chen,Xinyi Ma,Hanyi Zhu,Lisong Xie,Baoli Wang,Yanxiong Shao,Yijie Zhao,Yu Wei,Anni Hu,Zhanglong Zheng,Jiayao Fu,Lingyan Zheng +13 more
TL;DR: In this paper , Hect, uba, and wwe domain containing 1 (HUWE1), a member of the eukaryotic Hect E3 ubiquitin ligase family, plays a critical role in CD4+ T-cell activation and SS pathophysiology.
The predictive value of laboratory tests in oro-maxillofacial infection of different severity.
Baoli Wang,Wentao Qian,Zuoyi Yang,Chan Chen,Lingyan Zheng,Huan Shi +5 more
TL;DR: In this article , the authors investigated the value of individual laboratory tests and combinations of tests for predicting disease severity and found that leukocytes, neutrophils, C-reactive protein (CRP), procalcitonin (PCT), soluble interleukin receptor (sILR) 2, IL6, and creatinine (CR) increased as the severity of infection increased.
3
Accumulation of RIPK1 into mitochondria is requisite for oxidative stress-mediated necroptosis and proliferation in Rat Schwann cells
Baoli Wang,Jiayao Fu,Ying Chai,Yue-Fang Liu,Yanlin Chen,Junhao Yin,Yiping Pu,Chan Chen,JuFang Wang,Zhiyang Liu,Li Zheng,Minjie Chen +11 more
TL;DR: In this article , the authors identified an pivotal executor of necroptosis, RIPK1, performed an unique function in response to oxidative stress-induced injury in Rat Schwann cells.
3
Integrated analysis of m6A regulator-mediated RNA methylation modification patterns and immune characteristics in Sjögren's syndrome
Junhao Yin,Jiayao Fu,Jiabao Xu,Chan Chen,Hanyi Zhu,Baoli Wang,Chuangqi Yu,Xiujuan Yang,Ruiyu Cai,Mengyang Li,Kaihan Ji,Wanning Wu,Yijie Zhao,Zhanglong Zheng,Yiping Pu,Lingyan Zheng +15 more
TL;DR: A significant association between SS and altered expression of key m6A regulators and hub genes and a complex but discernible pattern of m6A modification that appears to be integrally linked with SS's pathogenesis are reported.