Chad W. MacPherson
McGill University Health Centre
20 Papers
20 Citations
Chad W. MacPherson is an academic researcher from McGill University Health Centre. The author has contributed to research in topics: Probiotic & Biology. The author has an hindex of 7, co-authored 16 publications.
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Papers
Gut Bacterial Microbiota and its Resistome Rapidly Recover to Basal State Levels after Short-term Amoxicillin-Clavulanic Acid Treatment in Healthy Adults
Chad W. MacPherson,Olivier Mathieu,Julien Tremblay,Julie Champagne,André Nantel,Stephanie-Anne Girard,Thomas A. Tompkins +6 more
TL;DR: Despite perturbations caused by short-term antibiotic treatment, both gut microbiota and resistome showed prompt recovery to baseline levels one week after cessation of the antimicrobial.
Multistrain Probiotic Modulation of Intestinal Epithelial Cells' Immune Response to a Double-Stranded RNA Ligand, Poly(I·C)
TL;DR: It is observed that the combination of the three bacteria had a major impact on attenuating the expression of genes connected to proinflammatory TH1 and antiviral innate immune responses compared to that obtained by the poly(I·C)-only challenge.
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Genome-Wide Immune Modulation of TLR3-Mediated Inflammation in Intestinal Epithelial Cells Differs between Single and Multi-Strain Probiotic Combination.
TL;DR: A synergistic effect of the bacterial combinations relative to the single strain and Lh-R0052-SLP treatments in resolving toll-like receptor 3 (TLR3)-induced inflammation in IEC and maintaining cellular homeostasis is indicated, reinforcing the rationale for using multi-strain formulations as a probiotic.
Probiotic Supplementation is Associated with Increased Antioxidant Capacity and Copper Chelation in C. difficile-Infected Fecal Water.
TL;DR: The findings suggest that C. difficile mediates dysregulation of redox status, which is counteracted by probiotics through ferric-reducing ability and copper chelation.
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Supplementation with Combined Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 Across Development Reveals Sex Differences in Physiological and Behavioural Effects of Western Diet in Long-Evans Rats.
Elizabeth M Myles,M Elizabeth O'Leary,Rylan Smith,Chad W. MacPherson,Alexandra Oprea,Emma H Melanson,Thomas A. Tompkins,Tara S. Perrot +7 more
- 05 Oct 2020
TL;DR: It was found that the probiotic formulation altered specific anxiety-like behaviours in adulthood and the greatest inflammatory response was seen in male, Western-diet-exposed, and probiotic-treated rats, which may be related to levels of specific steroid hormones in these groups.
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