21 Papers
172 Citations
Chad May is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Genetic enhancement & Globin. The author has an hindex of 13, co-authored 19 publications. Previous affiliations of Chad May include Pfizer & Cornell University.
Chat about Author
Papers
Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells
Jason M. Butler,Daniel J. Nolan,Eva L. Vertes,Barbara Varnum-Finney,Hideki Kobayashi,Andrea T. Hooper,Marco Seandel,Marco Seandel,Koji Shido,Ian A. White,Mariko Kobayashi,Larry Witte,Chad May,Carrie J. Shawber,Yuki Kimura,Jan Kitajewski,Zev Rosenwaks,Irwin D. Bernstein,Shahin Rafii +18 more
TL;DR: Angiogenic models are developed to demonstrate that EC-derived angiocrine growth factors support in vitro self-renewal and in vivo repopulation of authentic LT-HSCs, and establish an instructive vascular niche for clinical-scale expansion of LT- HSCs and a cellular platform to identify stem cell-active trophogens.
693
Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin
Chad May,Stefano Rivella,John Callegari,Glenn Heller,Karen M. L. Gaensler,Lucio Luzzatto,Michel Sadelain +6 more
TL;DR: It is shown that the use of recombinant lentiviruses enables efficient transfer and faithful integration of the human β-globin gene together with large segments of its locus control region, which should be of therapeutic benefit in patients with severe defects in haemoglobin production.
587
A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human β-globin gene transfer
TL;DR: An adult animal model for the most severe of the hemoglobinopathies, Cooley anemia, is established and the remarkable efficacy of lentivirus-mediated globin gene transfer in treating a fulminant blood disorder is demonstrated and strongly support the efficacy of gene therapy in the severe hemoglobinopathy.
247
Successful treatment of murine β-thalassemia intermedia by transfer of the human β-globin gene
TL;DR: These findings establish that a sustained increase of 3 to 4 g/dL hemoglobin is sufficient to correct ineffective erythropoiesis and demonstrate for the first time that viral-mediated globin gene transfer in hematopoietic stem cells effectively treats a severe hemoglobin disorder.
170
Mass Cultured Human Fibroblasts Overexpressing hTERT Encounter a Growth Crisis Following an Extended Period of Proliferation
TL;DR: Investigating the role of telomerase in immortalization by maintaining mass cultures of hTERT-transduced primary human fetal lung fibroblasts for very long periods of time indicates that h TERT-expressing cells may undergo crisis following an extended life span and that immortality is not the universal outcome of hterT expression in normal diploid fibro Blasts.
96