Chad M Estep
Northwestern University
8 Papers
50 Citations
Chad M Estep is an academic researcher from Northwestern University. The author has contributed to research in topics: Substantia nigra & Dopaminergic. The author has an hindex of 6, co-authored 8 publications. Previous affiliations of Chad M Estep include Michigan State University.
Chat about Author
Papers
Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's disease
Joshua A. Goldberg,Jaime N. Guzman,Chad M Estep,Ema Ilijic,Jyothisri Kondapalli,Javier Sanchez-Padilla,D. James Surmeier +6 more
TL;DR: In this article, the authors characterized neurons in the dorsal motor nucleus of the vagus (DMV), a population of cholinergic neurons that show signs of pathology in the early stages of Parkinson's disease, in mouse brain slices.
172
Many ways to be small: different environmental regulators of size generate distinct scaling relationships in Drosophila melanogaster
TL;DR: Examining the patterns of scaling in Drosophila melanogaster subjected to variation in three environmental regulators of size indicates that trait size is not simply a read-out of body size, but that different environmental factors may regulate body and trait size, and the relationship between the two, through different developmental mechanisms.
158
The fast and slow ups and downs of HCN channel regulation.
TL;DR: A focused review examining mechanisms of h channel regulation, with an emphasis on recent findings regarding interacting proteins such as TRIP8b is provided, intended to serve as a comprehensive resource for physiologists to provide potential molecular mechanisms underlying functionally important changes in Ih in different biological models.
55
Pedunculopontine glutamatergic neurons control spike patterning in substantia nigra dopaminergic neurons.
TL;DR: Optogenetic stimulation of PPN axons reliably evoked spiking in SNc dopaminergic neurons, suggesting that PPN-evoked burst spiking of SNc dopamine neurons in vivo may not only be extrinsic triggered, but extrinsically patterned as well.
43
Transient Activation of GABAB Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons.
Chad M Estep,Daniel J. Galtieri,Enrico Zampese,Joshua A. Goldberg,Lars Brichta,Paul Greengard,D. James Surmeier +6 more
TL;DR: In this article, perforated patch recordings were made from young adult mouse substantia nigra pars compacta (SNc) DA neurons, and the postsynaptic effects of GABA on SNc DA neurons are mediated by a mixture of GABAA and GABAB receptors.