Chad E. Townsend
University of California, Santa Cruz
13 Papers
12 Citations
Chad E. Townsend is an academic researcher from University of California, Santa Cruz. The author has contributed to research in topics: Membrane permeability & Chemistry. The author has an hindex of 6, co-authored 11 publications.
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Papers
Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility
Matthew R. Naylor,Andrew M Ly,Mason J Handford,Daniel P Ramos,Cameron R. Pye,Akihiro Furukawa,Victoria G. Klein,Ryan P Noland,Quinn Edmondson,Alexandra C Turmon,William M. Hewitt,Joshua Schwochert,Chad E. Townsend,Colin N Kelly,Maria-Jesus Blanco,R. Scott Lokey +15 more
TL;DR: It is shown that LPE provides a functional assessment of the efficiency with which a compound achieves passive membrane permeability at a given lipophilicity, especially relevant to "beyond rule of 5" molecules.
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Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules.
Cameron R. Pye,William M. Hewitt,Joshua Schwochert,Terra D. Haddad,Chad E. Townsend,Lyns Etienne,Yongtong Lao,Chris Limberakis,Akihiro Furukawa,Alan M. Mathiowetz,David Price,Spiros Liras,R. Scott Lokey +12 more
TL;DR: Using split-pool combinatorial synthesis, a library of cyclic, per-N-methlyated peptides is constructed spanning a wide range of calculated lipohilicities and molecular weights, revealing a steep drop-off in apparent passive permeability with increasing size in stark disagreement with current permeation models.
132
Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues.
Andrew T. Bockus,Joshua Schwochert,Cameron R. Pye,Chad E. Townsend,Vong Sok,Maria A. Bednarek,R. Scott Lokey +6 more
TL;DR: The structures of 17 sanguinamide A analogues designed to test the relative contributions of β-branching, N-methylation, and side chain size to passive membrane permeability and aqueous solubility are reported.
116
Understanding and Improving the Membrane Permeability of VH032-Based PROTACs
Victoria G. Klein,Chad E. Townsend,Andrea Testa,Michael Zengerle,Chiara Maniaci,Scott J. Hughes,Kwok-Ho Chan,Alessio Ciulli,R. Scott Lokey +8 more
TL;DR: The results show that the combination of these two cell-free membrane permeability assays provides new insight into PROTAC structure–permeability relationships and offers a conceptual framework for predicting the physicochemical properties of PROTACs in order to better inform the design of more permeable and more effective degraders.
109
CycLS: Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry
Chad E. Townsend,Akihiro Furukawa,Joshua Schwochert,Cameron R. Pye,Quinn Edmondson,R. Scott Lokey +5 more
TL;DR: An automated sequencing program, CycLS, is fast and provides a robust method for sequencing cyclic peptides that is particularly applicable to the deconvolution of synthetic libraries.
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