Cha Yang
Huazhong Agricultural University
9 Papers
4 Citations
Cha Yang is an academic researcher from Huazhong Agricultural University. The author has contributed to research in topics: Viral replication & Virus. The author has an hindex of 4, co-authored 7 publications.
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Papers
The Nucleolar Protein LYAR Facilitates Ribonucleoprotein Assembly of Influenza A Virus.
Cha Yang,Xiaokun Liu,Qingxia Gao,Tailang Cheng,Rong Xiao,Fan Ming,Shishuo Zhang,Meilin Jin,Huanchun Chen,Wenjun Ma,Hongbo Zhou +10 more
TL;DR: Improved understanding of interactions between host factors and vRNP increases basic knowledge of the molecular mechanisms of virus replication and pathogenicity but also provides insights into possible novel antiviral targets that are necessary due to the widespread emergence of drug-resistant IAV strains.
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Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
Qingxia Gao,Cha Yang,Caiyue Ren,Shishuo Zhang,Xiaochen Gao,Meilin Jin,Huanchun Chen,Wenjun Ma,Hongbo Zhou +8 more
TL;DR: EEF1D was identified as a novel inhibitor for the influenza virus life cycle and impaired the interaction between NP and importin α5 and the interactionBetween PB1 and RanBP5, which impeded the nuclear import of vRNP.
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HIST1H1C Regulates Interferon-β and Inhibits Influenza Virus Replication by Interacting with IRF3.
Xiaokun Liu,Cha Yang,Yong Hu,Erming Lei,Xian Lin,Lianzhong Zhao,Zhong Zou,Anding Zhang,Hongbo Zhou,Huanchun Chen,Ping Qian,Meilin Jin +11 more
TL;DR: This study reveals a novel function of H1C to regulate IFN-β and uncovers an underlying mechanism, which suggests H 1C plays a role in epigenetic regulation, and suggests a novel mechanism for the influenza virus to antagonize the innate immune response by NS2.
eIF4A3 Promotes RNA Viruses’ Replication by Inhibiting Innate Immune Responses
Qingxia Gao,Meijun Jiang,Yaxin Zhao,Guoli Li,Cha Yang,Caiyue Ren,Meilin Jin,Huanchun Chen,Hongbo Zhou +8 more
TL;DR: In this article , the authors identified eIF4A3 as a negative regulator of virus-triggered type I IFN induction, which impaired its biological functions in the nucleus.
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Patent
Construction and application of H9N2-subtype avian influenza virus cell high-yield vaccine strain
Zhou Hongbo,Jin Meilin,Bai Raoxian,Wang Yugang,Li Guoli,Chao Kang,Cha Yang +6 more
- 15 Jun 2016
TL;DR: In this paper, the 3rd, 5th and 8th loca of a 3'-terminal of an HA gene non-coding region of the isolate were subjected to artificial site-specific mutagenesis, and a mutation strain was saved through reverse genetic operation, wherein the mutation strain is subjected to passage on an MDCK cell until a stable generation to obtain a high-proliferation-titer virus strain, thereby producing the H9N2-subtype avian influenza virus cell vaccine.
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