12 Papers
6 Citations
CH Hwang is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Chemistry & Mycobacterium tuberculosis. The author has an hindex of 8, co-authored 12 publications.
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Papers
Low-Oxygen-Recovery Assay for High-Throughput Screening of Compounds against Nonreplicating Mycobacterium tuberculosis
TL;DR: This high-throughput, luminescence-based low-oxygen-recovery assay (LORA) was developed to screen antimicrobial agents against NRP Mycobacterium tuberculosis and is sufficiently robust for use for primary high- throughput screening of compounds against N RP M. tuberculosis.
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Indole alkaloids from two cultured cyanobacteria, Westiellopsis sp. and Fischerella muscicola
Hyunjung Kim,Daniel D. Lantvit,CH Hwang,David J. Kroll,Steven M. Swanson,Scott G. Franzblau,Jimmy Orjala +6 more
TL;DR: Chemical investigation of two cultured cyanobacteria led to the isolation of three hapalindole-type alkaloids, which showed potent activity against both Mycobacterium tuberculosis and Candida albicans with MIC values ranging from 0.6 to 2.5 μM.
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Bioautography with TLC-MS/NMR for Rapid Discovery of Anti-tuberculosis Lead Compounds from Natural Sources.
Edyta M. Grzelak,CH Hwang,Geping Cai,Joo Won Nam,Mary P. Choules,Wei Gao,David C. Lankin,James B. McAlpine,Surafel Mulugeta,José G. Napolitano,Joo Won Suh,Seung Hwan Yang,Jinhua Cheng,Hanki Lee,Jin Yong Kim,Sang-Hyun Cho,Guido F. Pauli,Scott G. Franzblau,Birgit U. Jaki +18 more
TL;DR: TLC-bioautography-MS/NMR, which combines cutting-edge microbiological, chromatographic, and spectrometric technologies, was developed to accelerate anti-tuberculosis drug discovery from natural sources by acquiring structural information at a very early stage of the isolation process.
Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward Mycobacterium tuberculosis
Michael W. Mullowney,CH Hwang,Andrew G. Newsome,Xiaomei Wei,Urszula Tanouye,Baojie Wan,Skylar Carlson,Nanthida Joy Barranis,Eoghainín Ó hAinmhire,Wei Lun Chen,Kalyanaraman Krishnamoorthy,John H. White,Rachel Blair,Hyunwoo Lee,Joanna E. Burdette,Pradipsinh K. Rathod,Tanya Parish,Sang-Hyun Cho,Scott G. Franzblau,Brian T. Murphy +19 more
TL;DR: This study establishes freshwater environments as potential sources for novel antibiotic leads and presents the diazaquinomycins as potent and selective inhibitors of M. tuberculosis.
New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos
Bethany G. Elkington,Bethany G. Elkington,Kongmany Sydara,Andrew G. Newsome,CH Hwang,David C. Lankin,Charlotte Simmler,José G. Napolitano,Richard H. Ree,James G. Graham,James G. Graham,Charlotte Gyllenhaal,Somsanith Bouamanivong,Onevilay Souliya,Guido F. Pauli,Scott G. Franzblau,Djaja Djendoel Soejarto,Djaja Djendoel Soejarto +17 more
TL;DR: This research has helped to increase awareness of Laos' rich diversity of medicinal plants and will hopefully provide incentive to preserve the undeveloped forested areas that remain, which still hold a wealth of medical information for future discoveries.
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