Cesare Balduini
University of Pavia
107 Papers
894 Citations
Cesare Balduini is an academic researcher from University of Pavia. The author has contributed to research in topics: Platelet & Thrombin. The author has an hindex of 30, co-authored 107 publications.
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Papers
Genetic evidence for a predominant role of PI3Kβ catalytic activity in ITAM- and integrin-mediated signaling in platelets
Ilaria Canobbio,Lucia Stefanini,Lina Cipolla,Elisa Ciraolo,Cristian Gruppi,Cesare Balduini,Emilio Hirsch,Mauro Torti +7 more
TL;DR: Genetic evidence is provided for a crucial and selective role of PI3Kbeta in signaling through GPVI and integrin alpha(IIb)beta(3) beta(3), and enzymatic activity was absolutely required for Akt phosphorylation, Rap1 activation, and platelet aggregation downstream of the immunoreceptor tyrosine-based activation motif (ITAM).
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A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B.
Paolo Lova,Simona Paganini,Emilio Hirsch,Laura Barberis,Matthias P. Wymann,Fabiola Sinigaglia,Cesare Balduini,Mauro Torti +7 more
TL;DR: It is concluded that stimulation of a Gi-dependent signaling pathway causes activation of the small GTPase Rap1B through the action of the PI3K product PtdIns(3,4,5)P3, but not Ptrisphosphate, and that this process may contribute to potentiation of platelet aggregation.
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Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A
Alessandro Malara,Cristian Gruppi,Paola Rebuzzini,Livia Visai,Cesare Perotti,Remigio Moratti,Cesare Balduini,Maria Enrica Tira,Alessandra Balduini +8 more
TL;DR: The data demonstrate that human MKs express and synthesize cellular fibronectin (cFN) and transglutaminase factor XIII-A (FXIII-A) and are involved in a new regulatory mechanism of MK-type I collagen interaction in the osteoblastic niche and demonstrate that MK adhesion to type I collagen promotes MK spreading and inhibits pro-platelet formation.
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Tyrosine phosphorylation of band 3 protein in Ca2+/A23187-treated human erythrocytes.
TL;DR: Observing tyrosine phosphorylation of band 3 when erythrocytes were induced to shrink in a Ca(2+)-independent manner, e.g. by treatment with the K+ ionophore valinomycin or with hypertonic solutions, suggests that band 3 tyrosining occurs when cell volume regulation is required.
Effect of polydeoxyribonucleotides on human fibroblasts in primary culture
TL;DR: The effects of a mixture of oligo‐ and polydeoxyribonucleotides (PDRN) on the growth and protein secretion of cultured human skin fibroblasts were investigated and stimulation appears to be specific for certain protein components, including fibronectin.
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