César Fandos
University of Barcelona
14 Papers
117 Citations
César Fandos is an academic researcher from University of Barcelona. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 8, co-authored 11 publications.
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Papers
Expanding antigen-specific regulatory networks to treat autoimmunity
Xavier Clemente-Casares,Jesús Blanco,Jesús Blanco,Poornima Ambalavanan,Jun Yamanouchi,Santiswarup Singha,César Fandos,Sue Tsai,Jinguo Wang,Nahir Garabatos,Cristina Izquierdo,Smriti M. Agrawal,Michael B. Keough,V. Wee Yong,Eddie A. James,Anna Moore,Yang Yang,Thomas Stratmann,Pau Serra,Pere Santamaria,Pere Santamaria +20 more
TL;DR: Systemic delivery of nanoparticles coated with autoimmune-disease-relevant peptides bound to major histocompatibility complex class II (pMHCII) molecules triggers the generation and expansion of antigen-specific regulatory CD4+ T cell type 1 (TR1)-like cells in different mouse models, leading to resolution of established autoimmune phenomena.
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Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices
Santiswarup Singha,Kun Shao,Yang Yang,Xavier Clemente-Casares,Patricia Solé,Antonio Clemente,Jesús Blanco,Qin Dai,Fayi Song,Shang Wan Liu,Jun Yamanouchi,Channakeshava Sokke Umeshappa,Roopa Hebbandi Nanjundappa,Pascal Detampel,Matthias Amrein,César Fandos,Robert L. Tanguay,Susan Newbigging,Pau Serra,Anmar Khadra,Warren C. W. Chan,Pere Santamaria +21 more
TL;DR: The engineering principles impacting biological activity are defined, a synthesis process yielding safe and stable compounds are detailed, and how these nanomedicines interact with cognate T cells are visualize.
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Myogenesis and MyoD Down-regulate Sp1 A MECHANISM FOR THE REPRESSION OF GLUT1 DURING MUSCLE CELL DIFFERENTIATION
Francesc Viñals,César Fandos,Tomàs Santalucía,Josep Ferré,Xavier Testar,Manuel Palacín,Antonio Zorzano +6 more
TL;DR: A regulatory model is suggested in which MyoD activation during myogenesis causes the down-regulation of Sp1, which contributes to the repression of GLUT1 gene transcription and, therefore, leads to the reduction inGLUT1 expression and glucose transport.
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Role of plasma membrane transporters in muscle metabolism.
TL;DR: The goal of this review is the molecular characterization of muscle membrane transporter proteins, as well as the analysis of their possible regulatory role.
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Factors Involved in GLUT-1 Glucose Transporter Gene Transcription in Cardiac Muscle
Tomàs Santalucía,Kenneth R. Boheler,Nigel J. Brand,Una Sahye,César Fandos,Francesc Viñals,Josep Ferré,Xavier Testar,Manuel Palacín,Antonio Zorzano +9 more
TL;DR: The results indicate that the expression of GLUT-1 andGLUT-4 in heart during perinatal development is largely controlled at a transcriptional level by mechanisms that might be related to hyperplasia and that are independent from the signals that trigger cell hypertrophy in the developing heart.
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