Ceren Ozek
Harvard University
6 Papers
1 Citations
Ceren Ozek is an academic researcher from Harvard University. The author has contributed to research in topics: Population & Gene. The author has an hindex of 3, co-authored 4 publications.
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Papers
Single-cell transcriptomic profiling of the aging mouse brain.
Methodios Ximerakis,Scott Lipnick,Brendan T. Innes,Sean Simmons,Xian Adiconis,Danielle Dionne,Brittany A Mayweather,Lan Nguyen,Zachary Niziolek,Ceren Ozek,Vincent L. Butty,Ruth Isserlin,Sean M. Buchanan,Stuart S. Levine,Aviv Regev,Gary D. Bader,Joshua Z. Levin,Lee L. Rubin,Lee L. Rubin +18 more
TL;DR: A single-cell transcriptomic atlas of the aging mouse brain reveals coordinated and cell-type-specific aging signatures across multiple cell populations, and highlights key molecular processes, including ribosome biogenesis, underlying brain aging.
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Lee Rubin: Our mentor and role model.
Chantal E. Bazenet,Howard Desmond,Eric Frank,Patrick Doherty,Andreas Eilers,Christine Gatchalian,Marcie A. Glicksman,Piotr Graczyk,Fabian Gusovsky,Jonathan Ham,David L. Kaplan,Michael Klymkoswsky,Karen Kotkow,Richard C. Krolewski,Paul Lang,Alison Linsley O'Neil,Mary Jane McCarthy,Karina F. Meiri,Freda D. Miller,Monica Mota Neumage,Ceren Ozek,Karen L. Philpott,Silvia Piccinotti,Feodor Price,Martin Raff,Marianne J. Ratcliffe,Jane Relton,Ken Rhodes,James E. Schwob,Caroline Smales,Terrence Smith,Cesare Spadoni,Joanne Taylor,Kostas Vekrellis,Jonny Whitfield +34 more
TL;DR: It is the collective experience of scientists who have worked with, been mentored by, or collaborated with Rubin that besides being an outstanding scientist, he is a warm and caring scientific mentor who does not deserve to have his reputation besmirched.
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Single-cell transcriptomics of the aged mouse brain reveals convergent, divergent and unique aging signatures
Methodios Ximerakis,Scott Lipnick,Sean Simmons,Xian Adiconis,Brendan T. Innes,Danielle Dionne,Lan Nguyen,Brittany A Mayweather,Ceren Ozek,Zachary Niziolek,Vincent L. Butty,Ruth Isserlin,Sean M. Buchanan,Stuart S. Levine,Aviv Regev,Gary D. Bader,Joshua Z. Levin,Lee L. Rubin +17 more
TL;DR: A single-cell transcriptomic analysis of young and old mouse brains provides a comprehensive dataset of aging-related genes, pathways and ligand-receptor interactions in nearly all brain cell types and reveals that aging, rather than inducing a universal program, drives a distinct transcriptional course in each cell population.
Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice
TL;DR: It is demonstrated that systemically delivered GDF11 enhances hippocampal neurogenesis, improves vasculature and increases markers of neuronal activity and plasticity in the hippocampus and cortex of old mice.
Author Correction: Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types.
Methodios Ximerakis,Kristina M Holton,Richard M. Giadone,Ceren Ozek,Monika Saxena,S J Santiago,Xian Adiconis,Danielle Dionne,Lan Nguyen,Kavya M Shah,Jill M. Goldstein,Caterina Gasperini,Ioannis A Gampierakis,Scott L Lipnick,Sean Simmons,Sean M. Buchanan,A. J. Wagers,Aviv Regev,Joshua Z. Levin,Lee L. Rubin +19 more