Céline Schmidt
2 Papers
Céline Schmidt is an academic researcher. The author has contributed to research in topics: Structure–activity relationship & In vivo. The author has an hindex of 2, co-authored 2 publications.
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Papers
Redefining the TGR5 triterpenoid binding pocket at the C-3 position
Cédric Genet,Céline Schmidt,Axelle Strehle,Kristina Schoonjans,Johan Auwerx,Régis Saladin,Alain Wagner +6 more
TL;DR: The structure-activity relationships between terpenoids and type 2 diabetes, and triterpenes and Derivatives Reference EPFL-ARTICLE-165507 are studied to propose a new strategy for quantifying the importance of these relationships to health.
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Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.
Cédric Genet,Axelle Strehle,Céline Schmidt,Geoffrey Boudjelal,Annelise Lobstein,Kristina Schoonjans,Michel Souchet,Johan Auwerx,Régis Saladin,Alain Wagner +9 more
TL;DR: The biological screening of a collection of natural occurring triterpenoids against the G protein-coupled receptor T GR5 revealed that betulinic, oleanolic, and ursolic acid exhibited TGR5 agonist activity in a selective manner compared to bile acids, which also activated FXR, the nuclear bile acid receptor.