Céline Loriol
Centre national de la recherche scientifique
5 Papers
Céline Loriol is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: SUMO protein & Gene silencing. The author has an hindex of 5, co-authored 5 publications.
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Papers
Activity‐dependent regulation of the sumoylation machinery in rat hippocampal neurons
TL;DR: This work has reported that the sumoylation process is developmentally regulated in the rat CNS, and its role in the regulation of nuclear homeostasis is still unclear.
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Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation
Anouar Khayachi,Carole Gwizdek,Gwénola Poupon,Damien Alcor,Magda Chafai,Frédéric Cassé,Thomas Maurin,Marta Prieto,Alessandra Folci,Fabienne De Graeve,Sara Castagnola,Romain Gautier,Lenka Schorova,Céline Loriol,Marie Pronot,Florence Besse,Frédéric Brau,Emmanuel Deval,Barbara Bardoni,Stéphane Martin +19 more
TL;DR: It is shown that FMRP sumoylation is required for regulating spine density and maturation, and is revealed as a critical activity-dependent regulatory mechanism of F MRP-mediated neuronal function.
mGlu5 receptors regulate synaptic sumoylation via a transient PKC-dependent diffusional trapping of Ubc9 into spines.
Céline Loriol,Frédéric Cassé,Anouar Khayachi,Gwénola Poupon,Magda Chafai,Emmanuel Deval,Carole Gwizdek,Stéphane Martin +7 more
TL;DR: The data demonstrate that Ubc9 diffusion is subject to activity-dependent regulatory processes and provide a mechanism for the dynamic changes in sumoylation occurring during synaptic transmission.
Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells.
David Crottès,Sonia Martial,Sonia Martial,Raphael Rapetti-Mauss,Raphael Rapetti-Mauss,Didier F. Pisani,Didier F. Pisani,Céline Loriol,Bernard Pellissier,Bernard Pellissier,Patrick Martin,Patrick Martin,Eric Chevet,Franck Borgese,Franck Borgese,Olivier Soriani,Olivier Soriani +16 more
TL;DR: It is shown that sigma ligands inhibit hERG current density and cell adhesion to fibronectin in K562 myeloid leukemia cells, demonstrating for the first time that Sig1R controls ion channel expression through the regulation of subunit trafficking activity.
Developmental regulation and spatiotemporal redistribution of the sumoylation machinery in the rat central nervous system.
Céline Loriol,Josephine Parisot,Gwénola Poupon,Gwénola Poupon,Carole Gwizdek,Carole Gwizdek,Stéphane Martin,Stéphane Martin +7 more
TL;DR: The data clearly demonstrate that thesumoylation process is developmentally regulated in the brain with high levels of nuclear sumoylation early in the development suggesting a role for this post-translational modification during the synaptogenesis period and a redistribution of the SUMO system towards dendritic spines at a later developmental stage to modulate synaptic protein function.