Céline Charon
8 Papers
134 Citations
Céline Charon is an academic researcher. The author has contributed to research in topics: Hereditary spastic paraplegia & Candidate gene. The author has an hindex of 8, co-authored 8 publications.
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Papers
Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14.
Bruno Etain,Flavie Mathieu,M. Rietschel,Wolfgang Maier,Margot Albus,Patrick McKeon,S. Roche,Carmel Kealey,Douglas Blackwood,Walter J. Muir,Frank Bellivier,C. Henry,Christian Dina,Sophie Gallina,Hugh Gurling,A. Malafosse,Martin Preisig,François Ferrero,Sven Cichon,Johannes Schumacher,Stephanie Ohlraun,Margitta Borrmann-Hassenbach,Peter Propping,R Abou Jamra,Thomas G. Schulze,Andrej Marusic,Z M Dernovsek,Bruno Giros,Thomas Bourgeron,Arnaud Lemainque,D Bacq,C Betard,Céline Charon,Markus M. Nöthen,Mark Lathrop,Marion Leboyer +35 more
TL;DR: This study is the first to use early-onset bipolar type I probands in an attempt to increase sample homogeneity and these preliminary findings require confirmation in independent panels of families.
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European collaborative study of early-onset bipolar disorder: Evidence for genetic heterogeneity on 2q14 according to age at onset†‡
Flavie Mathieu,Marie Hélène Dizier,Marie Hélène Dizier,Marie Hélène Dizier,Bruno Etain,Stéphane Jamain,Marcella Rietschel,Wolfgang Maier,Margot Albus,Patrick McKeon,S. Roche,Douglas Blackwood,Walter J. Muir,Chantal Henry,Alain Malafosse,Martin Preisig,François Ferrero,Sven Cichon,Johannes Schumacher,Stephanie Ohlraun,Peter Propping,Rami Abou Jamra,Thomas G. Schulze,Diana Zelenica,Céline Charon,Andrej Marusic,Mojca C. Dernovsek,Hugh Gurling,Markus M. Nöthen,Mark Lathrop,Marion Leboyer,Frank Bellivier +31 more
TL;DR: Analysis of the extended sample of families supports linkage in four regions (2q14, 3p14, 16p23, and 20p12) of the eight regions of linkage suggested by the previous genome scan and illustrates that stratification according to AAO may be valuable for the identification of genetic vulnerability polymorphisms.
A new phenotype linked to SPG27 and refinement of the critical region on chromosome.
Pascale Ribai,Giovanni Stevanin,Naima Bouslam,Bénédicte Pontier,Isabelle Nelson,Bertrand Fontaine,Christel Dussert,Céline Charon,Alexandra Durr,Alexis Brice +9 more
TL;DR: This is the first clinical description of a complicated form of spastic paraplegia, characterized by great phenotypic variability among the sibs, associated with the SPG27 locus.
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Refinement of the 2p11.1-q12.2 locus responsible for cortical tremor associated with epilepsy and exclusion of candidate genes
Cécile Saint-Martin,Delphine Bouteiller,Giovanni Stevanin,Cyprian Popescu,Céline Charon,Merle Ruberg,Stéphanie Baulac,Eric LeGuern,Pierre Labauge,Christel Depienne +9 more
TL;DR: A genome-wide scan using 370 microsatellite markers was performed on 11 family members and confirmed the existence of a common 40.27 Mb (33.73 cM) haplotype, segregating in all ten affected individuals and interrupted by a region of at least 5 Mb, likely corresponding to the same locus.
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Spastic paraplegia 5 : Locus refinement, candidate gene analysis and clinical description
Stephan Klebe,Alexandra Durr,Naima Bouslam,D. Grid,Caroline Paternotte,Christel Depienne,Sylvain Hanein,Sylvain Hanein,Ahmed Bouhouche,N. Elleuch,N. Elleuch,Hamid Azzedine,Hamid Azzedine,Sandrine Poëa-Guyon,Sylvie Forlani,Sylvie Forlani,Elodie Denis,Elodie Denis,Céline Charon,Jamilé Hazan,Alexis Brice,Giovanni Stevanin +21 more
TL;DR: The SPG5 locus was refined to a 3.8 cM interval and extended the phenotype of this form of ARHSP to include slight cerebellar signs and the direct sequencing of the coding exons of seven candidate genes did not detect mutations/polymorphisms in the index cases of both linked families.
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