Céline Ballandonne
University of Caen Lower Normandy
21 Papers
304 Citations
Céline Ballandonne is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 13, co-authored 21 publications.
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Papers
Toxicities of 48 pharmaceuticals and their freshwater and marine environmental assessment in northwestern France
Laetitia Minguez,Laetitia Minguez,Julie Pedelucq,Emilie Farcy,Emilie Farcy,Emilie Farcy,Céline Ballandonne,Hélène Budzinski,Marie-Pierre Halm-Lemeille +8 more
TL;DR: Results showed that no immediate acute toxicities were expected even if some compounds displayed strong toxicities at very low concentrations, and Antibiotics, antidepressants, and antifungals would deserve attention because of their high or median ecological risk suspected on marine and freshwater ecosystems.
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The use of urban sewage sludge on pastures: the cysticercosis threat.
TL;DR: Cysticercosis due to Taenia saginata appears to be one of the major pathological threats when sewage sludge is used to fertilise cattle pastures in temperate areas and future investigations should concentrate on the most sustainable means of reducing risk.
Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.
Christophe Rochais,Cédric Lecoutey,Florence Gaven,Florence Gaven,Florence Gaven,Patrizia Giannoni,Patrizia Giannoni,Patrizia Giannoni,Katia Hamidouche,Damien Hedou,Emmanuelle Dubost,David Genest,Samir Yahiaoui,Thomas Freret,Valentine Bouet,François Dauphin,Jana Sopkova-de Oliveira Santos,Céline Ballandonne,Sophie Corvaisier,Aurélie Malzert-Fréon,Rémi Legay,Michel Boulouard,Sylvie Claeysen,Sylvie Claeysen,Sylvie Claeysen,Patrick Dallemagne +25 more
TL;DR: The synthesis and in vitro evaluation of a novel series of multitarget-directed ligands displaying both nanomolar dual-binding site (DBS) acetylcholinesterase inhibitory effects and partial 5-HT4R agonist activity was described, among which donecopride was selected for further in vivo evaluations in mice.
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Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment
Cédric Lecoutey,Damien Hedou,Thomas Freret,Patrizia Giannoni,Florence Gaven,Marc Since,Valentine Bouet,Céline Ballandonne,Sophie Corvaisier,Aurélie Malzert Fréon,Serge Mignani,Thierry Cresteil,Michel Boulouard,Sylvie Claeysen,Christophe Rochais,Patrick Dallemagne +15 more
TL;DR: In this article, a multitarget-directed ligand that is able to exert not only a symptomatic but also, a disease-modifying effect against Alzheimer's disease (AD) was proposed.
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Acute toxicity of 8 antidepressants: What are their modes of action?
Laetitia Minguez,Laetitia Minguez,Emilie Farcy,Céline Ballandonne,Alban Lepailleur,Antoine Serpentini,Jean-Marc Lebel,Ronan Bureau,Marie-Pierre Halm-Lemeille +8 more
TL;DR: It is shown by molecular modeling that particular interactions can exist between antidepressants and phosphatidylcholine, a major component of cell membranes, leading to a more specific mode of action corresponding to a potential acidic hydrolysis of ester functions.
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