Célia Biane
Université Paris-Saclay
4 Papers
10 Citations
Célia Biane is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Biological network & Boolean network. The author has an hindex of 4, co-authored 4 publications.
Chat about Author
Papers
Causal Reasoning on Boolean Control Networks Based on Abduction: Theory and Application to Cancer Drug Discovery
Célia Biane,Franck Delaplace +1 more
TL;DR: This article presents a new method using abductive reasoning principles inferring the minimal causal topological actions leading to an expected behavior at stable state of disease-induced molecular perturbations and drug actions on molecular networks leading to cell phenotype reprogramming.
Abduction Based Drug Target Discovery Using Boolean Control Network
Célia Biane,Franck Delaplace +1 more
- 27 Sep 2017
TL;DR: A theoretical framework where mutations and drug actions are seen as topological perturbations/actions on molecular networks inducing cell phenotype reprogramming is proposed and a new algorithm using abductive reasoning principles inferring the minimal causal topological actions leading to an expected behavior at stable state is presented.
Abductive Network Action Inference for Targeted Therapy Discovery
TL;DR: A new computational method is proposed for network action inference using Boolean networks to model the dynamics of biological networks and where disease/drug actions are represented as arc additions and deletions and finds the actions that provide the best parsimonious explanation for shifting the cell from a diseased state to a healed state.
10
Networks and games for precision medicine.
TL;DR: A computational framework called Network-Action Game applied to best drug selection problem combining Game Theory and discrete models of dynamics (Boolean networks) is proposed, modelled using Game Theory that defines the process of drug selection among alternative possibilities.