Celeste J. Brown
University of Idaho
93 Papers
383 Citations
Celeste J. Brown is an academic researcher from University of Idaho. The author has contributed to research in topics: Gene & Plasmid. The author has an hindex of 42, co-authored 93 publications. Previous affiliations of Celeste J. Brown include Indiana University – Purdue University Indianapolis & Indiana University.
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Papers
Sequence complexity of disordered protein.
TL;DR: The Swiss Protein database of sequences exhibits significantly higher amounts of both low‐complexity and predicted‐to‐be‐disordered segments as compared to a non‐redundant set of sequences from the Protein Data Bank, providing additional data that nature is richer in disordered and low-complexity segments compared to the commonness of these features in the set of structurally characterized proteins.
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The importance of intrinsic disorder for protein phosphorylation
Lilia M. Iakoucheva,Predrag Radivojac,Celeste J. Brown,Celeste J. Brown,Timothy R. O'Connor,Jason G. Sikes,Zoran Obradovic,A. Keith Dunker +7 more
TL;DR: A new web-based tool for the prediction of protein phosphorylation sites, DISPHOS (DISorder-enhanced PHOSphorylation predictor, http://www.ist. edu/DISPHOS), which observes that amino acid compositions, sequence complexity, hydrophobicity, charge and other sequence attributes of regions adjacent to phosphate sites are very similar to those of intrinsically disordered protein regions.
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Intrinsic disorder in cell-signaling and cancer-associated proteins.
TL;DR: The data suggest that intrinsically unstructured proteins play key roles in cell-signaling, regulation and cancer, where coupled folding and binding is a common mechanism.
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Intrinsic protein disorder in complete genomes.
TL;DR: Overall, intrinsic disorder appears to be a common, with eucaryotes perhaps having a higher percentage of native disorder than archaea or bacteria, and bacteria and archaea in various archaea ranged from 2 to 11%, plus an apparently anomalous 18% in bacteria.
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