Cecil Han
Georgetown University
4 Papers
Cecil Han is an academic researcher from Georgetown University. The author has contributed to research in topics: Cytotoxic T cell & Interferon. The author has an hindex of 2, co-authored 4 publications. Previous affiliations of Cecil Han include University of Texas at Austin.
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Papers
Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.
Lifeng Yang,Abhinav Achreja,Tsz-Lun Yeung,Lingegowda S. Mangala,Dahai Jiang,Cecil Han,Joelle Baddour,Juan C. Marini,Joseph Ni,Ryuichi Nakahara,Stephen Wahlig,Lisa Chiba,Sun Hye Kim,Joshua Morse,Sunila Pradeep,Archana S. Nagaraja,Monika Haemmerle,Noh Kyunghee,Mathew Derichsweiler,Thomas Plackemeier,Imelda Mercado-Uribe,Gabriel Lopez-Berestein,Tyler J. Moss,Prahlad T. Ram,Jinsong Liu,Xiongbin Lu,Samuel C. Mok,Anil K. Sood,Deepak Nagrath +28 more
TL;DR: This work identifies a previously unrecognized mechanism whereby metabolism of reactive stromal cells is reprogrammed through an upregulated glutamine anabolic pathway and presents a synthetic lethal approach to target tumor stroma and cancer cells simultaneously for desirable therapeutic outcomes.
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Targeting DDX3X triggers anti-tumor immunity via a dsRNA-mediated tumor-intrinsic type I interferon response.
Hyeongjwa Choi,Juntae Kwon,Min Soon Cho,Yifan Sun,Xiaofeng Zheng,Jing Wang,Kerrie B. Bouker,John L. Casey,Michael B. Atkins,Jeffrey A. Toretsky,Cecil Han +10 more
TL;DR: Zhang et al. as discussed by the authors showed that the depletion of DEAD-box RNA helicase 3X (DDX3X) triggers a tumor-intrinsic type I IFN response in breast cancer cells.
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Inhibiting DDX3X Triggers Tumor-Intrinsic Type I Interferon Response and Enhances Anti-Tumor Immunity
Hyeongjwa Choi,Juntae Kwon,Jiafang Sun,Min Soon Cho,Yifan Sun,John L. Casey,Jeffrey A. Toretsky,Cecil Han +7 more
TL;DR: Zhang et al. as discussed by the authors showed that an RNA-binding protein, DEAD-box RNA helicase 3X (DDX3X), prevents the aberrant accumulation of cellular double-stranded RNAs.
USP13 interacts with cohesin and regulates its ubiquitination in human cells.
Xiaoyuan He,Jung-Sik Kim,Laura A. Díaz-Martínez,Cecil Han,William S. Lane,Bogdan Budnik,Todd Waldman +6 more
TL;DR: It is reported that mass spectrometry analysis of dual-affinity purifications identified the USP13 deubiquitinase as a novel cohesin-interacting protein that regulates the ubiquitination of cohes in and its cell cycle regulated interaction with chromatin.