Cecil Antony
University of Delhi
6 Papers
19 Citations
Cecil Antony is an academic researcher from University of Delhi. The author has contributed to research in topics: Gene expression & Gene knockdown. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Cecil Antony include International Centre for Genetic Engineering and Biotechnology.
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Papers
Suppression of TLR2-Induced IL-12, Reactive Oxygen Species, and Inducible Nitric Oxide Synthase Expression by Mycobacterium tuberculosis Antigens Expressed inside Macrophages during the Course of Infection
Deepti Gupta,Sachin Sharma,Jhalak Singhal,Akash Tripathi Satsangi,Cecil Antony,Krishnamurthy Natarajan +5 more
TL;DR: M. tuberculosis genes, expressed inside infected macrophages as a function of time, collectively suppress protective immune responses by using multiple and complementary mechanisms.
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Reciprocal Regulation of Reactive Oxygen Species and Phospho-CREB Regulates Voltage Gated Calcium Channel Expression during Mycobacterium tuberculosis Infection
Arti Selvakumar,Cecil Antony,Jhalak Singhal,Brijendra K Tiwari,Yogendra Singh,Krishnamurthy Natarajan +5 more
TL;DR: A dynamic reciprocal cross-regulation between ROS and pCREB was observed that in turn governed VGCC expression with ROS playing a limiting role in the process.
Regulation of L-type Voltage Gated Calcium Channel CACNA1S in Macrophages upon Mycobacterium tuberculosis Infection.
TL;DR: Investigation of mechanisms and key players that regulate the surface expression of VGCC-CACNA1S by Rv2463 and M. tb infection in macrophages finds an involvement of ER associated Stromal Interaction Molecules 1 and 2, and transcription factor pCREB, towards CAC NA1S expression that also involved the MyD88 independent pathway.
Mycobacterium tuberculosis and Human Immunodeficiency Virus Type 1 Cooperatively Modulate Macrophage Apoptosis via Toll Like Receptor 2 and Calcium Homeostasis.
Subhash Mehto,Cecil Antony,Nabab Khan,Rahul Arya,Arti Selvakumar,Brijendra K Tiwari,Mohit Vashishta,Yogendra Singh,Shahid Jameel,Krishnamurthy Natarajan +9 more
TL;DR: A synergistic effect of M. tuberculosis and HIV-1, and their antigens Rv3416 and Nef, respectively, in inhibiting apoptosis of macrophages is reported, involving the TLR2 pathway and second messengers that play complementing and contrasting roles in regulating apoptosis.
Suppression of Protective Responses upon Activation of L-Type Voltage Gated Calcium Channel in Macrophages during Mycobacterium bovis BCG Infection.
Deepika Sharma,Brijendra K Tiwari,Subhash Mehto,Cecil Antony,Gunjan Kak,Yogendra Singh,Krishnamurthy Natarajan +6 more
TL;DR: It is reported that activation of VGCC during infection synergistically downmodulates the generation of oxidative burst (ROS) by macrophages and mediates suppressor responses and prepare the macrophage for long term persistent infection.