Flexible pressure sensors can be used in human-computer interaction and wearable electronic devices, but one main challenge is to fabricate capacitive sensors with a wide pressure range and high sensitivity. Here, we designed a capacitive pressure sensor based on a bionic cheetah leg microstructure, validated the benefits of the bionic microstructure design, and optimized the structural feature parameters using 3D printing technology. The pressure sensor inspired by the cheetah leg shape has a high sensitivity (0.75 kPa-1), a wide linear sensing range (0-280 kPa), a fast response time of roughly 80 ms, and outstanding durability (24,000 cycles). Furthermore, the sensor can recognize a finger-operated mouse, monitor human motion, and transmit Morse code information. This work demonstrates that bionic capacitive pressure sensors hold considerable promise for use in wearable devices.

Flexible Capacitive Pressure Sensor with High Sensitivity and Wide Range Based on a Cheetah Leg Structure via 3D Printing.

This paper provides an overview of flexible and wearable respiration sensors with emphasis on their significance in healthcare applications. The paper classifies these sensors based on their operating frequency distinguishing between high-frequency sensors, which operate above 10 MHz, and low-frequency sensors, which operate below this level. The operating principles of breathing sensors as well as the materials and fabrication techniques employed in their design are addressed. The existing research highlights the need for robust and flexible materials to enable the development of reliable and comfortable sensors. Finally, the paper presents potential research directions and proposes research challenges in the field of flexible and wearable respiration sensors. By identifying emerging trends and gaps in knowledge, this review can encourage further advancements and innovation in the rapidly evolving domain of flexible and wearable sensors. 

Wearable Sensors for Respiration Monitoring: A Review

Flexible electronic devices have garnered significant attention due to their wide range of applications in evaluating the state of human wellness and intelligent robotics in long term. Microstructure flexible pressure...

Wearable flexible pressure sensors: An intriguing design towards microstructural functionalization

Foot activity can reflect numerous physiological abnormalities in the human body, making gait a valuable metric in health monitoring. Research on flexible sensors for gait monitoring has focused on high sensitivity, wide working range, fast response, and low detection limit, but challenges remain in areas such as elasticity, antibacterial activity, user-friendliness, and long-term stability. In this study, we have developed a novel capacitive pressure sensor that offers an ultralow detection limit of 1 Pa, wide detection ranges from 1 Pa to 2 MPa, a high sensitivity of 0.091 kPa-1, a fast response time of 71 ms, and exceptional stability over 6000 cycles. This sensor not only has the ability of accurately discriminating mechanical stimuli but also meets the requirements of elasticity, antibacterial activity, wearable comfort, and long-term stability for gait monitoring. The fabrication method of a dual dielectric layer and integrated composite electrode is simple, cost-effective, stable, and amenable to mass production. Thereinto, the introduction of a dual dielectric layer, based on an optimized electrospinning network and micropillar array, has significantly improved the sensitivity, detection range, elasticity, and antibacterial performance of the sensor. The integrated flexible electrodes are made by template method using composite materials of carbon nanotubes (CNTs), two-dimensional titanium carbide Ti3C2Tx (MXene), and polydimethylsiloxane (PDMS), offering synergistic advantages in terms of conductivity, stability, sensitivity, and practicality. Additionally, we designed a smart insole that integrates the as-prepared sensors with a miniature instrument as a wearable platform for gait monitoring and disease warning. The developed sensor and wearable platform offer a cutting-edge solution for monitoring human activity and detecting diseases in a noninvasive manner, paving the way for future wearable devices and personalized healthcare technologies. 

Capacitive Pressure Sensor Combining Dual Dielectric Layers with Integrated Composite Electrode for Wearable Healthcare Monitoring

The trade-off between sensitivity and linearity range for flexible capacitive pressure sensors remains unresolved. Herein, a simple and low-cost method is proposed to fabricate porous structure with the aid of negative pressure. The gradient dielectrics are assembled with porous structure doped with different CNT ratios. With the perforated design on the low dielectric layer, the gradient dielectric can realize series-parallel conversion during the pressure-induced deformation process, where the coverage ratio and dielectric properties of low dielectric layer can be appropriately collocated to realize the linear behavior of the capacitance performance over the full-scale pressure. Therefore, the capacitive sensor based on optimized gradient dielectric layer can achieve a high sensitivity of 0.247 kPa−1 and a wide linearity range of 0–175 kPa. With the high sensitivity over a broad pressure range, the capacitive sensor demonstrates its various practical applications in monitoring physiological signals and human motions such as the artery pulse, respiratory, knee bending, elbow bending degree and walking and running status, showing potential in wearable healthcare monitor. 

Negative Pressure-assisted Porous Structure With Gradient Dielectrics Design for Linearity Enhancement of Flexible Capacitance Pressure Sensor

Flexible positive pressure sensors have been studied extensively and have been used in a lot of scenarios. However, negative pressure detection is also in demand in some scenarios, such as fluid mechanics analysis, air pressure sensing, and so on. Flexible wearable sensors that can detect both positive and negative pressures will greatly broaden the application field. In this paper, we report a flexible highly sensitive ionic gel (IG) pressure sensor, which is simple and of low cost to prepare and can reliably detect a large pressure range from -98 to 100 kPa under an atmospheric pressure of about 982 hPa. The IG dielectric layer is composed of polyvinyl alcohol and phosphoric acid with a random microstructure of sandpaper inversion. The sensor exhibits flexibility, cycling stability, and high sensitivity under both negative and positive pressures (S = 84.45 nF/kPa for the negative pressure section, S = 25.61 nF/kPa for the positive pressure section). These sensors could be worn on the body not only to test breathing and pulse but also to measure air pressure for estimating the altitude, showing that the flexible full-pressure sensors have a wider application range in wearable electronics.

Flexible Wearable Capacitive Sensors Based on Ionic Gel with Full-Pressure Ranges.

Abstract In this study, we examined the combined impact of osteopontin (OPN) and treadmill training on mice with spinal cord injury (SCI). OPN was overexpressed by injecting AAV9-SPP1-GFP into the sensorimotor cortex, followed by a left incomplete C5 crush injury two weeks later. Mice (Ex or Ex + OPN group) were trained at 50% maximum running speed for 8 weeks. To analyze the effects, we used biotinylated dextran amine (BDA) for tracing the corticospinal tract (CST) and performed Western blotting and immunohistochemical methods to assess the activation of the mammalian target of rapamycin (mTOR). We also examined axonal regeneration and conducted behavioral tests to measure functional recovery. The results demonstrated that treadmill training promoted the expression of neurotrophic factors such as brain-derived neurotrophic factor (BNDF) and insulin-like growth factor I (IGF-1) and activated mTOR signaling. OPN amplified the effect of treadmill training on activating mTOR signaling indicated by upregulated phosphorylation of ribosomal protein S6 kinase (S6). The combination of OPN and exercise further promoted functional recovery and facilitated limited CST axonal regeneration which did not occur with treadmill training and OPN treatment alone. These findings indicate that OPN enhances the effects of treadmill training in the treatment of SCI and offer new therapeutic insights for spinal cord injury. 

Osteopontin enhances the effect of treadmill training and promotes functional recovery after spinal cord injury

Treg Upregulation by Treadmill Training Accelerates Myelin Repair Post-Ischemia.

Treadmill Training-Induced Remyelination Rescues Cognitive Impairment After Acute Hypoxia.

Growing evidence has proven the efficacy of physical exercise in remyelination and motor function performance after spinal cord injury (SCI). However, the molecular mechanisms of treadmill training on myelin repair and functional recovery after SCI have not yet been fully studied. Here, we explored the effect of treadmill training on upregulating peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1α)-mediated myelin repair and functional recovery in a mouse model of thoracic T10 contusion injury. A 4-week treadmill training scheme was conducted on mice with SCI. The expression levels of oligodendrogenesis-related protein and PGC1α were detected by immunofluorescence, RNA fluorescence in situ hybridization and western blotting. Transmission electron microscopy (TEM) was used to observe myelin structure. The Basso Mouse Scale (BMS) and CatWalk automated gait analysis system were used for motor function recovery evaluation. Motor evoked potentials (MEPs) were also identified. In addition, adeno-associated virus (AAV)-mediated PGC1α knockdown in OLs was used to further unravel the role of PGC1α in exercise-induced remyelination. We found that treadmill training boosts oligodendrocyte precursor cells (OPCs) proliferation, potentiates oligodendrocytes (OLs) maturation, and increases myelin-related protein and myelin sheath thickness, thus impelling myelin repair and hindlimb functional performance as well as the speed and amplitude of nerve conduction after SCI. Additionally, downregulating PGC1α through AAV attenuated these positive effects of treadmill training. Collectively, our results suggest that treadmill training enhances remyelination and functional recovery by upregulating PGC1α, which should provide a step forward in the understanding of the effects of physical exercise on myelin repair.

Myelin repair of spinal cord injury in adult mice induced by treadmill training upregulated peroxisome proliferator-activated receptor gamma coactivator 1 alpha.

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