Cathrin Gräwe
Radboud University Nijmegen
17 Papers
29 Citations
Cathrin Gräwe is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 4, co-authored 10 publications.
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Papers
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma.
Jiyeon Choi,Tongwu Zhang,Andrew Vu,Julien Ablain,Matthew M. Makowski,Leandro M. Colli,Mai Xu,Rebecca C Hennessey,Jinhu Yin,Harriet Rothschild,Cathrin Gräwe,Michael A. Kovacs,Karen M. Funderburk,Myriam Brossard,John C. Taylor,Bogdan Pasaniuc,Raj Chari,Stephen J. Chanock,Clive J. Hoggart,Florence Demenais,Jennifer H. Barrett,Matthew Law,Mark M. Iles,Kai Yu,Michiel Vermeulen,Leonard I. Zon,Kevin M. Brown +26 more
TL;DR: It is demonstrated that expression of one such gene, MX2, leads to the promotion of melanoma in a zebrafish model, and the integrative approach streamlines GWAS follow-up studies and highlights a pleiotropic function of MX2 in melanoma susceptibility.
BANP opens chromatin and activates CpG-island-regulated genes
Ralph S. Grand,Lukas Burger,Lukas Burger,Cathrin Gräwe,Alicia K. Michael,Luke Isbel,Luke Isbel,Daniel Hess,Leslie Hoerner,Vytautas Iesmantavicius,Sevi Durdu,Marco Pregnolato,Marco Pregnolato,Arnaud R Krebs,Sébastien A. Smallwood,Nicolas H. Thomä,Michiel Vermeulen,Dirk Schübeler,Dirk Schübeler +18 more
TL;DR: In this paper, single-molecule footprinting was combined with interaction proteomics to identify BTG-associated nuclear protein (BANP) as the transcription factor that binds the CGCG element in a DNA-methylation-dependent manner.
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RNA-Centric Methods: Toward the Interactome of Specific RNA Transcripts
TL;DR: An overview of methods to identify RNA-protein interactions can be found in this article, with a particular focus on strategies that provide insights into the interactome of specific RNA transcripts, including the potential of CRISPR-RNA targeting systems to investigate endogenous RNA−protein interactions.
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A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation.
Ezio T. Fok,Simone J.C.F.M. Moorlag,Yutaka Negishi,Laszlo A. Groh,Jéssica Cristina dos Santos,Cathrin Gräwe,Valerie Villacorta Monge,Daphne D. D. Craenmehr,Mellanie van Roosmalen,David Pablo da Cunha Jolvino,Letícia Busato Migliorini,Ary Serpa Neto,Patricia Severino,Michiel Vermeulen,L. A. Joosten,Mihai G. Netea,Stephanie Fanucchi,Musa M. Mhlanga +17 more
TL;DR: This work illuminates a chromatin-mediated biphasic circuit coordinating expression of IL-1β and IL-37, thereby regulating two functionally opposed states of inflammation from within a single TAD.
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PAQMAN: Protein-nucleic acid affinity quantification by MAss spectrometry in nuclear extracts.
TL;DR: Here, PAQMAN is applied to determine apparent affinities for a genetic variant, rs36115365-C, which regulates TERT expression and is associated with an increased risk to develop various malignancies.
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