Catherine Yao
University of Illinois at Urbana–Champaign
6 Papers
93 Citations
Catherine Yao is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Molecular imaging & Magnetic resonance imaging. The author has an hindex of 6, co-authored 6 publications.
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Papers
Investigating the optimal size of anticancer nanomedicine
Li Tang,Xujuan Yang,Qian Yin,Kaimin Cai,Hua Wang,Isthier Chaudhury,Catherine Yao,Qin Zhou,Mincheol Kwon,James A. Hartman,Iwona T. Dobrucki,Lawrence W. Dobrucki,Luke B. Borst,Stéphane Lezmi,William G. Helferich,Andrew L. Ferguson,Timothy M. Fan,Jianjun Cheng +17 more
TL;DR: Among the three NCs investigated, the 50-nm NC shows the highest tumor tissue retention integrated over time, which is the collective outcome of deep tumor tissue penetration and efficient cancer cell internalization as well as slow tumor clearance, and thus, the highest efficacy against both primary and metastatic tumors in vivo.
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Helical antimicrobial polypeptides with radial amphiphilicity
Meng-Hua Xiong,Michelle W. Lee,Rachael A. Mansbach,Ziyuan Song,Yan Bao,Richard M. Peek,Catherine Yao,Lin Feng Chen,Andrew L. Ferguson,Gerard C. L. Wong,Jianjun Cheng +10 more
TL;DR: The design of a class of cationic, helical homo-polypeptide antimicrobials with a hydrophobic internal helical core and a charged exterior shell, possessing unprecedented radial amphiphilicity is reported, allowing improved permeation of commercial antibiotics in bacteria and enhanced antimicrobial activity by one to two orders of magnitude.
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Suppression of Hepatic Inflammation via Systemic siRNA Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles
Hua He,Nan Zheng,Ziyuan Song,Kyung Hoon Kim,Catherine Yao,Rujing Zhang,Chenglin Zhang,Yuhui Huang,Fatih M. Uckun,Jianjun Cheng,Yanfeng Zhang,Lichen Yin +11 more
TL;DR: It is verified that the bioactive secondary structure of polypeptides significantly dominates the in vivo siRNA delivery efficiency, and the unique properties of PPABLG HNPs render remarkable potentials for anti-inflammation therapies.
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Supramolecular Self‐Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF‐α siRNA against Systemic Inflammation
Lichen Yin,Ziyuan Song,Qiuhao Qu,Kyung Hoon Kim,Nan Zheng,Catherine Yao,Isthier Chaudhury,Haoyu Tang,Nathan P. Gabrielson,Fatih M. Uckun,Jianjun Cheng +10 more
TL;DR: Owing to the infiltration of GAMs to systemic reticuloendothelial tissues, Map4k4 siRNA-mediated TNF-α knockdown in GAMs extended to other tissues and thus induced systemic anti-inflammatory effects, and was recently exemplified by a report of attenuating systemic inflammation by targeting orally delivered Map4K4 si RNA to gut-associated macrophages.
Redox-responsive, reversibly-crosslinked thiolated cationic helical polypeptides for efficient siRNA encapsulation and delivery.
Nan Zheng,Ziyuan Song,Yang Liu,Rujing Zhang,Ruoyan Zhang,Catherine Yao,Fatih M. Uckun,Lichen Yin,Jianjun Cheng +8 more
TL;DR: With the collective contribution of the potent membrane activity and redox-responsive cargo release profiles, the crosslinked complexes enable efficient gene silencing without appreciable cytotoxicity, thus providing a potential strategy for polypeptide-based intracellular siRNA delivery.
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