Catherine Smith
Children's Hospital of Philadelphia
6 Papers
29 Citations
Catherine Smith is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: DNA methylation & Myeloid leukemia. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Catherine Smith include University of Pennsylvania.
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Papers
A clinical measure of DNA methylation predicts outcome in de novo acute myeloid leukemia
Marlise R. Luskin,Phyllis A. Gimotty,Catherine Smith,Alison W. Loren,Maria E. Figueroa,Jenna Harrison,Zhuoxin Sun,Martin S. Tallman,Elisabeth Paietta,Mark R. Litzow,Ari Melnick,Ross L. Levine,Hugo F. Fernandez,Selina M. Luger,Martin Carroll,Stephen R. Master,Gerald Wertheim +16 more
TL;DR: The M-score represents a valid binary prognostic classifier for patients with de novo AML and can be used for prognosis and should be further investigated for clinical decision making in AML patients.
Validation of DNA Methylation to Predict Outcome in Acute Myeloid Leukemia by Use of xMELP
Gerald Wertheim,Catherine Smith,Marlise R. Luskin,Alison Rager,Maria E. Figueroa,Martin Carroll,Stephen R. Master +6 more
TL;DR: The results demonstrate that xMELP performance is suitable for implementation in the clinical laboratory and predicts AML outcome in an independent patient cohort and the sensitivity of the random forest classifier score to failure at 1 or more loci.
12
Microsphere-based multiplex analysis of DNA methylation in acute myeloid leukemia.
Gerald Wertheim,Gerald Wertheim,Catherine Smith,Maria E. Figueroa,Michael Kalos,Adam Bagg,Martin Carroll,Stephen R. Master +7 more
TL;DR: A novel strategy is developed, termed microsphere HpaII tiny fragment enrichment by ligation-mediated PCR (MELP), to simultaneously analyze the DNA methylation pattern at these loci using methylation-specific DNA digestion, fluorescently labeled microspheres, and branched DNA hybridization.
10
Validation of a clinical assay of multi‐locus DNA methylation for prognosis of newly diagnosed AML
Courtney D. DiNardo,Marlise R. Luskin,Martin Carroll,Catherine Smith,Jenna Harrison,Sherry Pierce,Steve Kornblau,Marina Konopleva,Tapan M. Kadia,Hagop M. Kantarjian,Gerald Wertheim,Stephen R. Master +11 more
TL;DR: In this paper, the authors developed a clinical assay to assess multi-locus DNA methylation (xMELP), and a companion random forest classification system (M-score) for AML patient prognosis.
10
Efficient recovery of fluoroquinolone-susceptible and fluoroquinolone-resistant Escherichia coli strains from frozen samples.
Ebbing Lautenbach,Evelyn Santana,Abby Lee,Pam Tolomeo,Nicole Black,Andrew Babson,Eli N. Perencevich,Anthony D. Harris,Catherine Smith,Joel N. Maslow +9 more
TL;DR: The findings emphasize the utility of frozen surveillance samples and highlight the importance of knowing which strains are likely to be present in low numbers in the initial sample.