Catherine M. Flanley
University of Notre Dame
3 Papers
4 Citations
Catherine M. Flanley is an academic researcher from University of Notre Dame. The author has contributed to research in topics: Genetic variability & Epitope. The author has an hindex of 2, co-authored 3 publications.
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Papers
Population genetics analysis of Phlebotomus papatasi sand flies from Egypt and Jordan based on mitochondrial cytochrome b haplotypes
Catherine M. Flanley,Marcelo Ramalho-Ortigao,Iliano V. Coutinho-Abreu,Rami Mukbel,Hanafi A. Hanafi,Shabaan S. El-Hossary,Emad El Din Y. Fawaz,David F. Hoel,Alexander W. Bray,Gwen Stayback,Douglas A. Shoue,Shaden Kamhawi,Mehmet Karakuş,Kaouther Jaouadi,Mohammad Reza Yaghoobie-Ershadi,Andreas Krüger,Ahmad Amro,Mohamed A. Kenawy,Mostafa Ramadhan Dokhan,Alon Warburg,Omar Hamarsheh,Mary Ann McDowell +21 more
TL;DR: Pockets of genetic differentiation exists between populations of this widely dispersed species but, overall, the species remains relatively homogeneous.
Phlebotomus papatasi sand fly predicted salivary protein diversity and immune response potential based on in silico prediction in Egypt and Jordan populations.
Catherine M. Flanley,Marcelo Ramalho-Ortigao,Iliano V. Coutinho-Abreu,Rami Mukbel,Hanafi A. Hanafi,Shabaan S. El-Hossary,Emadeldin Y. Fawaz,David F. Hoel,Alexander W. Bray,Gwen Stayback,Douglas A. Shoue,Shaden Kamhawi,Scott J. Emrich,Mary Ann McDowell +13 more
TL;DR: Investigating the variability in the predicted protein sequences of nine of the most abundantly expressed salivary proteins from field populations found two of the predicted sequences demonstrated low genetic variability across the three geographic isolated sand fly populations, with conserved multiple predicted MHCII epitope binding sites suggestive of their potential application in vaccination approaches.
Phlebotomus papatasi sand fly salivary protein diversity and immune response potential in Egypt and Jordan populations
Catherine M. Flanley,Marcelo Ramalho-Ortigao,Coutinho-Abreu,Rami Mukbel,Hanafi A. Hanafi,Shabaan S. El-Hossary,Emad El Din Y. Fawaz,David F. Hoel,Alexander W. Bray,Gwen Stayback,Douglas A. Shoue,Shaden Kamhawi,Scott J. Emrich,Mary Ann McDowell +13 more
TL;DR: Analyzing the genetic variability of nine of the most abundantly expressed salivary proteins revealed greater allelic variation across the same sand fly populations indicating that their use as vaccine targets may prove to be challenging.