Catherine A. Oleykowski
Fox Chase Cancer Center
8 Papers
81 Citations
Catherine A. Oleykowski is an academic researcher from Fox Chase Cancer Center. The author has contributed to research in topics: DNA & Nuclease. The author has an hindex of 8, co-authored 8 publications.
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Papers
Mutation detection using a novel plant endonuclease
TL;DR: The results indicate that CEL I mutation detection is a highly sensitive method for detecting both polymorphisms and disease-causing mutations in DNA fragments as long as 1120 bp in length.
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Purification, cloning, and characterization of the CEL I nuclease.
Bing Yang,Xiao Wen,Nagendra S. Kodali,Catherine A. Oleykowski,C. Glenn Miller,Joanne Kulinski,David Besack,Jason A. Yeung,David Kowalski,Anthony T. Yeung +9 more
TL;DR: It is proposed that CEL I exemplifies a new family of neutral pH optimum, magnesium-stimulated, mismatch duplex-recognizing nucleases, within the S1 superfamily, which includes nucleases putatively encoded by the genes BFN1 of Arabidopsis, ZEN1 of Zinnia, and DSA6 of daylily.
Repair of aflatoxin B1 DNA adducts by the UvrABC endonuclease of Escherichia coli.
Catherine A. Oleykowski,Janet A. Mayernik,Susan E. Lim,John D. Groopman,Lawrence Grossman,Gerald N. Wogan,Anthony T. Yeung +6 more
TL;DR: The observation that the a flatoxin B1.N7-guanine lesion is removed rapidly, while the aflatoxin B 1-formamidopyrimidine lesion persists in the mammalian cell may have other mechanistic explanations.
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Incision at Nucleotide Insertions/Deletions and Base Pair Mismatches by the SP Nuclease of Spinach†
TL;DR: It is shown that an outstanding substrate for SP is a mismatched DNA duplex, and the inability of SP to cut at guanine residues and the favoring of A-T-rich regions distinguish SP from the CEL I family of neutral pH mismatch endonucleases recently discovered in celery and other plants.
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Recombinant nucleases CEL I from celery and SP I from spinach for mutation detection
Maxim Pimkin,Elena Caretti,Adrian Canutescu,Jeffrey B Yeung,Heather Cohn,Yibai Chen,Catherine A. Oleykowski,Alfonso Bellacosa,Anthony T. Yeung +8 more
TL;DR: The insect cell-expressed CEL I orthologs may not be identical to their native counterparts purified from plant tissues, and the present expression system should facilitate further development of Cel I-based mutation detection technologies.