Catherijne A. J. Knibbe
Leiden University
282 Papers
849 Citations
Catherijne A. J. Knibbe is an academic researcher from Leiden University. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 49, co-authored 242 publications. Previous affiliations of Catherijne A. J. Knibbe include Erasmus University Medical Center & Utrecht University.
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Papers
Pharmacokinetics and Pharmacodynamics of Drugs in Obese Pediatric Patients: How to Map Uncharted Clinical Territories
TL;DR: To improve knowledge on drug pharmacology in obese pediatric patients, studies should focus on quantifying the impact of maturation, obesity, and other relevant variables on primary pharmacological parameters and on disentangling systemic and presystemic clearance.
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•Journal Article
Individualized dosing guidelines for children
Catherijne A. J. Knibbe,Dick Tibboel,Saskia N. de Wildt,Matthijs de Hoog,Mathieu M. Tjoeng,Meindert Danhof +5 more
TL;DR: Insight into the pharmacokinetics and pharmacodynamics of drugs should serve as the basis for dosing in children, and the 'population approach' should be chosen to minimize the burden for the child.
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Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools
TL;DR: The EBE test was found to be a fast and accurate tool for covariate preselection in RTTE models and the novel Schoenfeld-like residual test proposed here had a similar performance in the tested scenarios and might be applied more readily to time-varying covariates, such as drug concentration and dynamic biomarkers.
Predicting Unacceptable Pain in Cardiac Surgery Patients Receiving Morphine Maintenance and Rescue Doses: A Model-Based Pharmacokinetic-Pharmacodynamic Analysis.
Sebastiaan C. Goulooze,Elke H. J. Krekels,Mohammed A A Saleh,Sabine J.G.M. Ahlers,P. Välitalo,Eric P.A. van Dongen,Ron H.N. van Schaik,Thomas Hankemeier,Dick Tibboel,Catherijne A. J. Knibbe +9 more
TL;DR: The pharmacodynamics of morphine after cardiac surgery was successfully quantified using RTTE modeling and future studies can be used to expand the model to better predict morphine's pharmacodynamics on the individual level and to include the pharmacodynamic of other analgesics so that improved postoperative pain treatment protocols can be developed.
Total bodyweight and sex both drive pharmacokinetic variability of fluconazole in obese adults.
Lu Chen,K. van Rhee,Roeland E Wasmann,Elke H. J. Krekels,Marinus J. Wiezer,Eric P.A. van Dongen,Paul E. Verweij,P. D. Van Der Linden,Roger J. M. Brüggemann,Catherijne A. J. Knibbe +9 more
TL;DR: In the population of obese but otherwise healthy individuals, obesity clearly alters the pharmacokinetics of fluconazole, which puts severely obese adults, particularly if male, at risk of suboptimal exposure, for which adjusted doses are proposed.