Caterina Miro
University of Naples Federico II
31 Papers
7 Citations
Caterina Miro is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 6, co-authored 13 publications.
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Papers
Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch
Caterina Miro,Emery Di Cicco,Raffaele Ambrosio,Giuseppina Mancino,Daniela Di Girolamo,Annunziata Gaetana Cicatiello,Serena Sagliocchi,Annarita Nappi,Maria Angela De Stefano,Cristina Luongo,Dario Antonini,Feliciano Visconte,Silvia Varricchio,Gennaro Ilardi,Luigi Del Vecchio,Stefania Staibano,Anita Boelen,Cédric Blanpain,Caterina Missero,Domenico Salvatore,Monica Dentice +20 more
TL;DR: It is reported that intracellular activation of thyroid hormone by the D2 deiodinase enzyme promotes invasion and progression of squamous cell carcinoma by transcriptionally up-regulating ZEB-1 and supports the concept that TH is an EMT promoter.
Thyroid hormone and androgen signals mutually interplay and enhance inflammation and tumorigenic activation of tumor microenvironment in prostate cancer.
Caterina Miro,Angelo di Giovanni,Melania Murolo,Annunziata Gaetana Cicatiello,Annarita Nappi,Serena Sagliocchi,Emery Di Cicco,Francesco Morra,Angela Celetti,Francesco Pacifico,Ciro Imbimbo,Felice Crocetto,Monica Dentice +12 more
TL;DR: In this article , the authors found that the intracellular TH metabolism is a crucial determinant of prostate cancer behavior and that a dynamic stage-specific expression of the THs modulating enzymes, the deiodinases, is required for the progression of BPH to PCa malignancy.
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The thyroid hormone activating enzyme, type 2 deiodinase, induces myogenic differentiation by regulating mitochondrial metabolism and reducing oxidative stress.
Serena Sagliocchi,Annunziata Gaetana Cicatiello,Emery Di Cicco,Raffaele Ambrosio,Caterina Miro,Daniela Di Girolamo,Annarita Nappi,Giuseppina Mancino,Maria Angela De Stefano,Cristina Luongo,Maddalena Raia,Ashley N. Ogawa-Wong,Ann Marie Zavacki,Simona Paladino,Domenico Salvatore,Monica Dentice +15 more
TL;DR: The findings indicate that TH plays a key role in oxidative stress dynamics by regulating ROS generation and the novel finding that TH and its intracellular metabolism act as mitochondrial detoxifying agents sheds new light on metabolic processes relevant to muscle physiology.
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"time" for obesity-related cancer: the role of the circadian rhythm in cancer pathogenesis and treatment.
Caterina Miro,A. Docimo,Luigi Barrea,L. Verde,Simona Cernea,Antoan Stefan Sojat,Ljiljana Marina,Giovanni Docimo,Annamaria Colao,Monica Dentice,Giovanna Muscogiuri +10 more
TL;DR: In this paper , the aberrant circadian rhythms affect the development and prognosis of different types of obesity-related cancers (breast, prostate, colon rectal and thyroid cancer) focusing on both human studies and on molecular aspects.
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Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage
Annarita Nappi,Caterina Miro,Antonio Pezone,Alfonso Tramontano,Emery Di Cicco,Serena Sagliocchi,Annunziata Gaetana Cicatiello,Melania Murolo,Sepehr Torabinejad,Elena Abbotto,Giuseppina Caiazzo,Maddalena Raia,Mariano Stornaiuolo,Dario Antonini,Gabriella Fabbrocini,Domenico Salvatore,Vittorio Enrico Avvedimento,Monica Dentice +17 more
TL;DR: In this paper , the authors show that the cell stress sensor and tumor suppressor p53 silences D2 expression, thereby lowering the intracellular THs availability, and even partial loss of p53 elevates D2/TH resulting in stimulation and increased fitness of tumor cells by boosting a significant transcriptional program.