Cassuto Jp
University of Nice Sophia Antipolis
21 Papers
193 Citations
Cassuto Jp is an academic researcher from University of Nice Sophia Antipolis. The author has contributed to research in topics: Chronic myelogenous leukemia & K562 cells. The author has an hindex of 16, co-authored 21 publications.
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Papers
Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation
Alexandre Puissant,Guillaume Robert,Nina Fenouille,Frederic Luciano,Cassuto Jp,Sophie Raynaud,Patrick Auberger +6 more
TL;DR: It is concluded that RSV triggered autophagic cell death in CML cells via both JNK-mediated p62 overexpression and AM PK activation, and the findings show that the JNK and AMPK pathways can cooperate to eliminate C ML cells via autophagy.
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The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCδ and proteasome-dependent regulation of Mcl-1 expression
A D Baudot,P Y Jeandel,Xavier Mouska,Ulrich Maurer,Sophie Tartare-Deckert,Sophie Tartare-Deckert,S D Raynaud,Cassuto Jp,Michel Ticchioni,Marcel Deckert,Marcel Deckert +10 more
TL;DR: It is concluded that spleen tyrosine kinase constitutes a key regulator of B-CLL cell survival, emphasizing the clinical utility of Syk inhibition in hematopoietic malignancies.
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Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
Michel Ticchioni,Makram Essafi,P Y Jeandel,Frederic Davi,Cassuto Jp,Marcel Deckert,Alain Bernard,Alain Bernard +7 more
TL;DR: The data support the notion that homeostatic chemokines contribute to B-CLL resistance to cell death through inactivation of the transcription factor FOXO3a, which may represent a novel therapeutic target in this hematopoietic malignancy.
108
Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line.
Pascal Colosetti,Alexandre Puissant,Guillaume Robert,Frederic Luciano,Arnaud Jacquel,Pierre Gounon,Cassuto Jp,Patrick Auberger +7 more
TL;DR: This is the first description that induction of autophagy is involved in megakaryocytic differentiation of K562 CML cells and the combination of PMA+SB appears to induces both increase in autophagic fluxes and an Autophagic degradation blockage.
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Imatinib mesylate (STI571) decreases the vascular endothelial growth factor plasma concentration in patients with chronic myeloid leukemia
Laurence Legros,Christine Bourcier,Arnaud Jacquel,Francois-Xavier Mahon,Cassuto Jp,Patrick Auberger,Gilles Pagès +6 more
TL;DR: The aim of this study was to determine the capacity of imatinib mesylate to modulate one of the most potent regulators of angiogenesis, the vascular endothelial growth factor (VEGF), and to demonstrate the potential prognostic value of VEGF concentrations in evaluating the evolution of CML patients treated with Imatinib.
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