Cassi M. Bruni
University of California, San Diego
3 Papers
1 Citations
Cassi M. Bruni is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Kupffer cell & Cellular differentiation. The author has an hindex of 2, co-authored 3 publications.
Chat about Author
Papers
Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.
Jason S. Seidman,Ty D. Troutman,Mashito Sakai,Anita Gola,Nathanael J. Spann,Hunter Bennett,Cassi M. Bruni,Zhengyu Ouyang,Rick Z. Li,Xiaoli Sun,Bao Chau T. Vu,Martina P. Pasillas,Kaori M. Ego,David Gosselin,Verena M. Link,Ling Wa Chong,Ronald M. Evans,Bonne M. Thompson,Jeffrey G. McDonald,Mojgan Hosseini,Joseph L. Witztum,Ronald N. Germain,Christopher K. Glass +22 more
TL;DR: Findings reveal mechanisms by which disease-associated environmental signals instruct resident and recruited macrophages to acquire distinct gene expression programs and corresponding functions.
340
Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity.
Mashito Sakai,Ty D. Troutman,Jason S. Seidman,Zhengyu Ouyang,Nathanael J. Spann,Yohei Abe,Kaori M. Ego,Cassi M. Bruni,Zihou Deng,Johannes C. M. Schlachetzki,Alexi Nott,Hunter Bennett,Jonathan Chang,Bao Chau T. Vu,Martina P. Pasillas,Verena M. Link,Verena M. Link,Lorane Texari,Sven Heinz,Bonne M. Thompson,Jeffrey G. McDonald,Frederic Geissmann,Christopher K. Glass +22 more
TL;DR: Analysis of transcriptomic and epigenetic changes in repopulating liver macrophages following acute Kupffer cell depletion provides a framework for understanding how macrophage progenitor cells acquire tissue-specific phenotypes.
322
Niche-Specific Re-Programming of Epigenetic Landscapes Drives Myeloid Cell Diversity in NASH
Jason S. Seidman,Ty D. Troutman,Mashito Sakai,Anita Gola,Nathanael J. Spann,Hunter Bennett,Cassi M. Bruni,Zhengyu Ouyang,Rick Z. Li,Xiaoli Sun,BaoChau T. Vu,Martina P. Pasillas,Kaori M. Ego,David Gosselin,Verena M. Link,Ling-Wa Chong,Ronald M. Evans,Bonne M. Thompson,Jeffrey G. McDonald,Mojgan Hosseini,Ronald N. Germain,Joseph L. Witztum,Christopher K. Glass +22 more
TL;DR: Mechanisms by which disease-associated environmental signals instruct resident and recruited macrophages to acquire distinct programs of gene expression and corresponding phenotypes are revealed.
3