Cassi Estrem
University of Colorado Denver
8 Papers
11 Citations
Cassi Estrem is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Biology & Connectome. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Cassi Estrem include Massachusetts Institute of Technology.
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Papers
Brain-wide representations of behavior spanning multiple timescales and states in C. elegans
Adam Atanas,Jungsoo Kim,Ziyu Wang,Eric Bueno,McCoy Becker,Di Kang,Jungyeon Park,T. S. Kramer,Flossie K. Wan,Saba N. Baskoylu,Ugur Dag,E. Kalogeropoulou,Matthew A. Gomes,Cassi Estrem,Netta Cohen,Vikash K. Mansinghka,Steven W. Flavell +16 more
TL;DR: This work recorded brain-wide activity and the diverse motor programs of freely moving C. elegans and built probabilistic models that explain how each neuron encodes quantitative behavioral features, which provide a global map of how the cell types across an animal's brain encode its behavior.
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Dissecting the functional organization of the C. elegans serotonergic system at whole-brain scale
Ugur Dag,Ijeoma Nwabudike,Di Kang,Matthew A. Gomes,Jungsoo Kim,Adam Atanas,Eric Bueno,Cassi Estrem,Sarah Pugliese,Ziyu Wang,Emma K. Towlson,Steven W. Flavell +11 more
TL;DR: In this paper , the authors examined how serotonin release in C. elegans alters brain-wide activity to induce foraging behaviors, like slow locomotion and increased feeding, and mapped all sites of serotonin receptor expression in the connectome, which, together with synaptic connectivity, helps predict which neurons show serotonin-associated activity.
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High-resolution Imaging and Analysis of Individual Astral Microtubule Dynamics in Budding Yeast.
TL;DR: This method, combined with conventional yeast genetics, provides an approach that is uniquely suited for quantitatively assessing the effects of microtubule regulators or mutations that alter the activity of tubulin subunits.
Help or hindrance: how do microtubule-based forces contribute to genome damage and repair?
Cassi Estrem,Jeffrey K. Moore +1 more
TL;DR: It is found that increased nuclear movement results in DNA damage and increased time to repair the damage through homology-directed repair, which sets up an apparent paradox, where genome mobility may prevent or promote DNA repair.
11
Astral microtubule forces alter nuclear organization and inhibit DNA repair in budding yeast.
Cassi Estrem,Jeffrey K. Moore +1 more
TL;DR: This study investigates how forces on astral microtubules impact the genome during cell division by using live-cell imaging of the cytoskeleton, chromatin, and DNA damage repair in budding yeast and proposes that minimizing nuclear movement aids in finding a donor strand for homologous recombination.