Cassandra Styke
University of Queensland
6 Papers
11 Citations
Cassandra Styke is an academic researcher from University of Queensland. The author has contributed to research in topics: Progenitor cell & Endothelium. The author has an hindex of 1, co-authored 2 publications.
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Papers
Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors.
Jilai Zhao,Jatin Patel,Jatin Patel,Simranpreet Kaur,Seen Ling Sim,Ho Yi Wong,Cassandra Styke,Isabella Hogan,Sam L. Kahler,Hamish Hamilton,Racheal Wadlow,James Dight,Ghazaleh Hashemi,Laura Sormani,Edwige Roy,Mervin C. Yoder,Mathias Francois,Kiarash Khosrotehrani +17 more
TL;DR: In this article, the authors show that conditional knock-out of Sox9 from the vasculature (Sox9fl/fl/Cdh5-CreER RosaYFP) depletes EVP while enhancing Rbpj expression and canonical Notch signalling.
Resident vascular endothelial progenitor definition and function: the age of reckoning
TL;DR: The existence of a progenitor population within the endothelium has been validated through the study of endothelial colony-forming cells (ECFCs) in human peripheral blood and certain vascular beds as discussed by the authors.
Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium.
Jilai Zhao,Laura Sormani,Sebastien Jacquelin,Haiming Li,Cassandra Styke,Chenhao Zhou,Jonathan Beesley,Linus Oon,Simranpreet Kaur,Seen-Ling Sim,Ho Yi Wong,James Dight,Ghazaleh Hashemi,Abbas Shafiee,Edwige Roy,Kiarash Khosrotehrani +15 more
TL;DR: This study investigates the impact of oxidized low-density lipoprotein (oxLDL) on endothelial progenitor cells, revealing that SOX9 activation drives Endothelial-to-Mesenchymal Transition (EndMT), impairing self-renewal and promoting a mesenchymal phenotype.
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1511 Macrophages regulate endothelial progenitors’ quiescence and self-renewal during homeostasis and cutaneous wound healing via paracrine signaling
Seen-Ling Sim,Simmer Kaur,Cassandra Styke,Susan M. Millard,Alyssa Blumenthal,Allison R. Pettit,Kiarash Khosrotehrani +6 more
TL;DR: In this article , perivascular macrophage (PVM) was identified in the blood vessel vicinity during tissue homeostasis and wound healing, and the physiological role of these PVMΦ on EPCs' function in wound re-vascularisation remains elusive.
1459 PDGFRA-expressing endovascular progenitors contribute to differentiated endothelium of aorta and wounds
Cassandra Styke,Simmer Kaur,Seen-Ling Sim,J. Zhao,Ali Akbar Shafiee,C S Zhou,Hayes Wong,Kiarash Khosrotehrani +7 more
TL;DR: In this paper , the authors examined the overlap of several of these markers with recently identified endovascular progenitors (EVPs), shown to have functional progenitor capacity, in homeostatic murine aorta and full-skin excisional wounds.