Carsten Kummerow

TL;DR: It is shown that expression of the mitochondrial calcium uniporter (MCU), the selective channel responsible for mitochondrial Ca2+ uptake, correlates with tumor size and lymph node infiltration, suggesting that mitochondrial Ca 2+ uptake might be instrumental for tumor growth and metastatic formation.

TL;DR: It is found that the subplasmalemmal calcium signal following IS formation is sufficiently low to prevent calcium‐dependent inactivation of ORAI channels, and plasma membrane calcium ATPases (PMCAs) are re‐distributed into areas beneath mitochondria, which prevented PMCA up‐modulation and decreased calcium export locally.

TL;DR: Genome-wide ChIP-seq data indicate that NFATc1 is an important regulator of cytotoxic T lymphocyte effector functions, and this work shows it controls the cytotoxicity and metabolic switching of activated CD8+ T cells required for optimal response to bacteria and tumor cells.

TL;DR: Basic oxygen redox chemistry and methods of ROS detection with special emphasis on electron paramagnetic resonance (EPR) spectroscopy are reviewed and the present knowledge of redox regulation of Ca(2+) permeable ion channels such as voltage-gated Ca( 2+) channels, transient receptor potential (TRP) channels and Orai channels is focused on.