Carsten Krieg
Medical University of South Carolina
52 Papers
119 Citations
Carsten Krieg is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Immune system & Biology. The author has an hindex of 27, co-authored 43 publications. Previous affiliations of Carsten Krieg include University of Zurich & University Hospital of Lausanne.
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Papers
High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy
Carsten Krieg,Malgorzata Nowicka,Malgorzata Nowicka,Silvia Guglietta,Sabrina Schindler,Felix J. Hartmann,Lukas M. Weber,Lukas M. Weber,Reinhard Dummer,Mark D. Robinson,Mark D. Robinson,Mitchell P. Levesque,Burkhard Becher +12 more
TL;DR: High-dimensional single-cell mass cytometry and a bioinformatics pipeline are used for the in-depth characterization of the immune cell subsets in the peripheral blood of patients with stage IV melanoma before and after 12 weeks of anti-PD-1 immunotherapy to propose that the frequency of monocytes in PBMCs may serve in clinical decision support.
Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
Aron M. Levin,Darren L. Bates,Aaron M. Ring,Carsten Krieg,Jack T. Lin,Leon Su,Ignacio Moraga,Miro E. Raeber,Gregory R. Bowman,Paul Novick,Vijay S. Pande,C. Garrison Fathman,Onur Boyman,K. Christopher Garcia +13 more
TL;DR: In vitro evolution has mimicked the functional role of CD25 in enhancing IL-2 potency and regulating target cell specificity, which has implications for immunotherapy.
Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells
TL;DR: It is shown that IL-2–induced pulmonary edema is caused by direct interaction of Il-2 with functional IL- 2 receptors (IL-2R) on lung endothelial cells in vivo, and IL-1/anti-IL-1 antibody complexes might improve current strategies of IL–2–based tumor immunotherapy.
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CyTOF workflow: differential discovery in high-throughput high-dimensional cytometry datasets
Malgorzata Nowicka,Malgorzata Nowicka,Carsten Krieg,Helena L. Crowell,Helena L. Crowell,Lukas M. Weber,Lukas M. Weber,Felix J. Hartmann,Silvia Guglietta,Burkhard Becher,Mitchell P. Levesque,Mark D. Robinson,Mark D. Robinson +12 more
TL;DR: An updated R-based pipeline for differential analyses of HDCyto data, largely based on Bioconductor packages is presented, allowing overdispersion in cell count or aggregated signals across samples to be appropriately modeled.
Homeostatic proliferation and survival of naïve and memory T cells.
TL;DR: The factors controlling T‐cell homeostasis can be seen to vary considerably from one subset to another as described in detail in this review.
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