Carsten Gartung
RWTH Aachen University
65 Papers
471 Citations
Carsten Gartung is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Cholestasis & Organic anion transporter 1. The author has an hindex of 28, co-authored 63 publications. Previous affiliations of Carsten Gartung include Yale University & Boston Children's Hospital.
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Papers
Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis.
Carsten Gartung,Meenakshisundaram Ananthanarayanan,Mohammed A. Rahman,Stephan Schuele,Surajit Nundy,Carol J. Soroka,Andrew Stolz,Frederick J. Suchy,James L. Boyer +8 more
TL;DR: Extrahepatic cholestasis results in rapid down-regulation of Na(+)-dependent taurocholate uptake, ntCP transcription, and posttranscriptional regulation of both ntcp and 3 alpha-HSD mRNA.
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Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis.
Andreas Geier,Christoph G. Dietrich,Sebastian Voigt,Suk-Kyum Kim,Thomas Gerloff,Gerd A. Kullak-Ublick,Johann Lorenzen,Siegfried Matern,Carsten Gartung +8 more
TL;DR: TNF‐α represents the master cytokine responsible for HNF1‐dependent down‐regulation of Ntcp, Oatp1, and Oat p2 in CCl4‐induced toxic liver injury and H NF1 and RXR/RAR‐independent mechanisms appear to be more important in regulation of Mrp2 and NtCP gene expression in endotoxemia.
217
Association of polymorphisms of the transforming growth factor-β1 gene with the rate of progression of HCV-induced liver fibrosis
TL;DR: The results indicate that the heterozygous ArgPro of codon 25 predicts significantly faster fibrotic progression of chronic hepatitis C than the homozygous (25)ArgArg genotype, which does not show any correlation with stage, grade or progression of liver fibrosis.
124
Interleukin-6 regulates hepatic transporters during acute-phase response.
Elmar Siewert,Christoph G. Dietrich,Frank Lammert,Peter C. Heinrich,Siegfried Matern,Carsten Gartung,Andreas Geier +6 more
TL;DR: Induction of an aseptic and septic acute-phase response leads to the down-regulation of basolateral and canalicular organic anion transporters in IL-6-deficient mice.
112
Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver
Andreas Geier,Christoph G. Dietrich,Sebastian Voigt,Meenakshisundaram Ananthanarayanan,Frank Lammert,Anne Schmitz,Michael Trauner,Hermann E. Wasmuth,Diana Boraschi,Natarajan Balasubramaniyan,Frederick J. Suchy,Siegfried Matern,Carsten Gartung +12 more
TL;DR: Transporter mRNA expression was determined by Northern blot analysis, nuclear activity, and protein-expression of transactivators by EMSA and Western blotting, and downregulates Bsep, Mrp2, and Mrp3 mRNAs to some extent to study transcriptional regulation.
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