Carrie Ho
Duke University
6 Papers
24 Citations
Carrie Ho is an academic researcher from Duke University. The author has contributed to research in topics: Simian immunodeficiency virus & Virus. The author has an hindex of 3, co-authored 6 publications.
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Papers
Tenascin-C is an innate broad-spectrum, HIV-1–neutralizing protein in breast milk
Genevieve G. Fouda,Frederick H. Jaeger,Joshua D. Amos,Carrie Ho,Erika L. Kunz,Kara Anasti,Lisa Stamper,Brooke E. Liebl,Kimberly H. Barbas,Tomoo Ohashi,M.A. Moseley,Hua-Xin Liao,Harold P. Erickson,S. Munir Alam,Sallie R. Permar +14 more
TL;DR: The ability of an innate mucosal host protein found in milk to neutralize HIV-1 via binding to the chemokine coreceptor site is demonstrated, potentially explaining why the majority of HIV–1–exposed breastfed infants are protected against mucosal HIV- 1 transmission.
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Lack of B Cell Dysfunction Is Associated with Functional, gp120-Dominant Antibody Responses in Breast Milk of Simian Immunodeficiency Virus-Infected African Green Monkeys
Joshua D. Amos,Andrew B. Wilks,Genevieve G. Fouda,Shannon D. Smith,Lisa Colvin,Tatenda Mahlokozera,Carrie Ho,Krista Beck,R. Glenn Overman,C. Todd DeMarco,Terry L. Hodge,Celia C. LaBranche,David C. Montefiori,Thomas N. Denny,Hua-Xin Liao,Georgia D. Tomaras,M. Anthony Moody,Sallie R. Permar +17 more
TL;DR: Interestingly, lactating, SIV-infected African green monkeys (AGMs) exhibited robust milk and plasma Env binding antibody responses that were one to two logs higher than those in RhMs and humans and demonstrated autologous neutralizing responses in milk at 1 year postinfection.
Transient Compartmentalization of Simian Immunodeficiency Virus Variants in the Breast Milk of African Green Monkeys
Carrie Ho,Steven H. Wu,Joshua D. Amos,Lisa Colvin,Shannon D. Smith,Andrew B. Wilks,C. Todd DeMarco,Christie Brinkley,Thomas N. Denny,Joern E. Schmitz,Allen G. Rodrigo,Sallie R. Permar +11 more
TL;DR: Preliminary phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs found low-diversity milk virus populations were compartmentalized from that in plasma, however, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally.
Breast Milk of African Green Monkeys Immunodeficiency Virus Variants in the Transient Compartmentalization of Simian
Allen G. Rodrigo,Sallie R. Permar,Christie Brinkley,Thomas N. Denny,Joern E. Schmitz,Shannon D. Smith,Andrew B. Wilks,C. Todd DeMarco,Carrie Ho,Steven H. Wu,Joshua D. Amos,Lisa Colvin +11 more
- 01 Jan 2014
TL;DR: Understanding the mechanisms underlying the rarity of breast milk transmission in natural hosts of SIV could guide the development of interventions to impede postnatal HIV-1 trans-mission.
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Transient Compartmentalization of SIV Variants in the Breast Milk of
Carrie Ho,Steven H. Wu,Jonathon E. Himes,Joshua D. Amos,Lisa Colvin,C. Todd DeMarco,Christie Brinkley,Thomas N. Denny,Allen G. Rodrigo,Sallie R. Permar +9 more
- 01 Jan 2013
TL;DR: As there is a genetic bottleneck in postnatal virus transmission, the restricted diversity of breast milk virus variants and the limited number of CCR5-expressing CD4+ target cells in infant AGMs may together contribute to the rarity of postnatal transmission in natural hosts.